gene 1,784 words KG: AIM2
Contents

AIM2 Gene

🧬 Gene Info
Gene SymbolAIM2
AliasesAIM2, PYHIN4
Chromosome6q25.1
Protein FamilyHIN-200 (PYHIN) family
FunctionAIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular LocalizationCytoplasm
Molecular Weight39 kDa
Amino Acids200 aa
Gene TypeProtein-coding
PathwaysApoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt IDQ9UMG1
NCBI Gene ID199
Ensembl IDENSG00000163568
GeneCardsAIM2
Human Protein AtlasAIM2
Associated DiseasesALS, Atherosclerosis, Cancer, Dementia, Infection
InteractionsZBP1, MLKL, TLR9, RIPK1, PYCARD, UBIQUITIN
KG Connections410 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N
Score: 0.58
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re
Score: 0.58
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu
Score: 0.58
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57

Related Analyses (2)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: activates
ATG14 Gene
gene · KG edge: activates
ASC (PYCARD)
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

AIM2 associated_with TNF
AIM2 associated_with MARCH7
AIM2 associated_with PYCARD
AIM2 associated_with LAMP1
AIM2 associated_with ASC
AIM2 associated_with ATG5
AIM2 associated_with CASP1
AIM2 associated_with IL1B
AIM2 associated_with NLRC4
AIM2 associated_with NLRP3