protein

ATG13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

196Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG13 is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with Aging, Als, Atherosclerosis. Connected to 104 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATG13
Full Name	Autophagy Related 13
Chromosome	11p11.2
Function	is a critical gene encoding a key regulator of the autophagy initiation machinery in eukaryotic cells.
Molecular Weight	60 kDa
Amino Acids	559 aa
Pathways	Apoptosis, Autophagy, Complement, Ferroptosis, Glycolysis
UniProt ID	[Q9UQL6](https://www.uniprot.org/uniprot/Q9UQL6)
Ensembl ID	ENSG00000152256
OMIM	614608
GeneCards	ATG13
Human Protein Atlas	ATG13
Hor domain (HR)	Located at the N-terminus, mediates protein-protein interactions
LIR (LC3-interacting region)	At the C-terminus, enables binding to LC3/GABARAP family proteins
UBAN-like motif	Facilitates interaction with specific autophagy receptors
Associated Diseases	neurodegeneration
Interactions	NCOA4, RAB7A, FUNDC1, ATG14, BECN1, BCL2L13
KG Connections	196 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG13["ATG13"] -->|"regulates"| autophagy["autophagy"]
    ATG13["ATG13"] -->|"contributes to"| Ferroptosis["Ferroptosis"]
    ATG13["ATG13"] -->|"activates"| Cancer["Cancer"]
    ATG13["ATG13"] -->|"interacts"| Als["Als"]
    ATG13["ATG13"] -->|"interacts"| Ms["Ms"]
    ATG13["ATG13"] -->|"interacts"| Parkinson["Parkinson"]
    ATG["ATG"] -->|"component of"| ATG13["ATG13"]
    ATG5["ATG5"] -->|"contributes to"| ATG13["ATG13"]
    ATG3["ATG3"] -->|"contributes to"| ATG13["ATG13"]
    ATG7["ATG7"] -->|"contributes to"| ATG13["ATG13"]
    style ATG13 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (125)

Target	Relation	Type	Str
autophagy	regulates	pathway	0.90
Ferroptosis	contributes_to	process	0.85
autophagy pathway	participates_in	pathway	0.80
ULK1	interacts_with	gene	0.70
Autophagy	interacts_with	pathway	0.70
AUTOPHAGY	interacts_with	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Cancer	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Senescence	activates	disease	0.65
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
FERROPTOSIS	contributes_to	phenotype	0.64
ATG5	contributes_to	gene	0.60
BECN1	contributes_to	gene	0.60
NCOA4	activates	gene	0.60
ATG7	contributes_to	gene	0.60
RAB7A	activates	gene	0.60
ATG4B	contributes_to	gene	0.60
ATG3	contributes_to	gene	0.60
FUNDC1	interacts_with	gene	0.60
TAX1BP1	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
TBK1	regulates	gene	0.60
ATG14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
ATG7	associated_with	gene	0.60
ATG16L1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NDP52	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
ATG9A	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
ULK1	activates	gene	0.60
FIP200	associated_with	gene	0.60

Incoming (71)

Source	Relation	Type	Str
ATG	component_of	gene	0.80
ATG5	contributes_to	gene	0.60
ATG3	contributes_to	gene	0.60
ATG7	contributes_to	gene	0.60
BNIP3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
ATG5	associated_with	gene	0.60
ATG16L1	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
P62	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
STX17	regulates	gene	0.60
ULK1	associated_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
TAX1BP1	associated_with	gene	0.60
ATG101	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
ATG1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
MTOR	activates	gene	0.60
FIP200	activates	gene	0.60
CAV1	activates	gene	0.60
GAL	activates	gene	0.60
NCOA4	activates	gene	0.60
ATG4B	contributes_to	gene	0.60
NBR1	associated_with	gene	0.60
RAB7A	activates	gene	0.60
BECN1	contributes_to	gene	0.60
APP	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
HSP70	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ATG16L1	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
HSP90	inhibits	gene	0.60
EIF2A	activates	gene	0.60
HSP27	inhibits	gene	0.60
C9ORF72	interacts_with	gene	0.60
BECLIN1	inhibits	gene	0.60
LC3	inhibits	gene	0.60
ATG101	regulates	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
AGING	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG13

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG13 — Autophagy Related 13

cbs-psp-daily-action-plan

rapamycin-tauopathy

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

autophagy-lysosome-dysfunction

Mitochondrial Unfolded Protein Response in Neurodegeneration

Lysosomal Dysfunction in Progressive Supranuclear Palsy

mTOR Signaling in Neurodegeneration

Autophagy-Lysosomal Pathway

Autophagy Types in Neurodegeneration

autophagy

mTOR Signaling in Parkinson's Disease

ATG7 Protein — Autophagy-Related Protein 7

Autophagy-Lysosome Pathway in Neurodegeneration

fip200

Autophagy-Enhancing Therapies

CBS Autophagy-Lysosomal Pathway Dysfunction

CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease

Autophagy Enhancers for PD