gene 672 words KG: AURKB 2026-03-17
kind:genesection:genesstate:published
Contents

AURKB Gene

🧬 Gene Info
Gene SymbolAURKB
AliasesAURORA-B, STK12
Chromosome17p13.1
Functionis a chromosome passenger complex protein essential for mitosis and cytokinesis.
Subcellular Localization. The CPC, composed of Aurora B, survivin (BIRC5), INCENP, and Borealin, targets Aurora B to the inner centromere during
Gene TypeProtein Coding
UniProt IDQ96GD4
NCBI Gene ID921
Ensembl IDENSG00000178999
GeneCardsAURKB
Human Protein AtlasAURKB
Gene NameAurora Kinase B
Protein ProductAurora B kinase (AurB)
Expression PatternUbiquitous; highest during mitosis
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsMYC, CALM1, KIF5B, PVALB, SST, RANK
KG Connections88 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.38

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
NEFL — Neurofilament Light Chain
gene · KG edge: associated_with
NEFH — Neurofilament Heavy Chain
gene · KG edge: associated_with
MYC Gene
gene · KG edge: activates
KIF5B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

AURKB activates MYC
AURKB interacts_with CALM1
AURKB associated_with TPR
AURKB therapeutic_target RANK
AURKB associated_with NEFH
AURKB interacts_with KIF5B
AURKB associated_with CDC42
AURKB interacts_with PVALB
AURKB interacts_with SST
AURKB associated_with GAP43