gene 879 words KG: H2AX 2026-03-29
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:dna-repair
Contents

H2AX Gene

🧬 Gene Info
Gene SymbolH2AX
AliasesH2A.X, H2AFX
Chromosome11q23.2
FunctionH2AX is a variant histone that comprises ~2-10% of the H2A pool in mammalian cells.
PathwaysApoptosis, Proteasome, Ubiquitin-Proteasome
UniProt IDP16104
NCBI Gene ID3014
GeneCardsH2AX
Human Protein AtlasH2AX
ProteinFunction
ATMPhosphorylation
ATRKinase
MDC1Binding
MRN ComplexSensor
BRCA1Recruitment
Associated DiseasesALS, Neurodegeneration, Parkinson, Senescence
InteractionsAURKB, TLR4, FUS, ATM, CDKN1A, P62
KG Connections293 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

PARP1 Inhibition Therapy
Score: 0.58
R-Loop Resolution Enhancement Therapy
Score: 0.43
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
BAX Gene
gene · KG edge: activates
AURKB Gene
gene · KG edge: activates
ATR Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

H2AX regulates OCLN
H2AX regulates RAC1
H2AX regulates PIK3C3
H2AX associated_with ATG14
H2AX associated_with GJA1
H2AX regulates LAMP1
H2AX expressed_in GBM
H2AX expressed_in CDK2
H2AX regulates ATR
H2AX therapeutic_target ATM