gene 1,022 words KG: BMI1 2026-03-21
kind:genesection:genesstate:published
Contents

BMI1

🧬 Gene Info
Gene SymbolBMI1
Full NameBMI1 Proto-Oncogene, Polycomb Ring Finger
AliasesPCGF4, RNF51, FLVI2
Chromosome10p12.2
Functionencodes a core component of the Polycomb Repressive Complex 1 (PRC1).
Gene TypeProtein-coding
PathwaysEpigenetic
UniProt IDP35226
Ensembl IDENSG00000168283
OMIM164831
GeneCardsBMI1
Human Protein AtlasBMI1
HGNC1048
Entrez Gene648
rs7900170Intronic
Associated Diseasesneurodegeneration
InteractionsDNA, APOPTOSIS
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39

Related Analyses (4)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
CEBPB Gene
gene · KG edge: regulates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

BMI1 regulates CEBPB
BMI1 activates Cancer
BMI1 activates Als
BMI1 activates Amyotrophic Lateral Sclerosis
BMI1 therapeutic_target Fibrosis
BMI1 regulates Als
BMI1 therapeutic_target Aging
BMI1 therapeutic_target Tgf-Β
BMI1 inhibits DNA
BMI1 inhibits Tumor