gene 2,732 words KG: C1R
Contents

C1R — Complement Component 1, R Subcomponent

🧬 Gene Info
Gene SymbolC1R
Full NameComplement Component 1, R Subcomponent
Chromosome12p13.31
Protein TypeProtease
Functionis a critical component of the innate immune system, providing defense against pathogens and contributing to tissue homeostasis.
Primary Expressionthe brain, where they participate in synaptic remodeling, neuroinflammation, and neurodegenerative processes
PathwaysComplement
UniProt IDP09871
NCBI Gene ID715
Ensembl IDENSG00000159403
OMIM216950
GeneCardsC1R
Human Protein AtlasC1R
Encoded ProteinC1r protease
Associated DiseasesAging, Alzheimer, Senescence
InteractionsCD47, SIRPA, C1S, CLN5, CR1, PARP1
KG Connections93 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Complement C1q Mimetic Decoy Therapy
Score: 0.48
Complement C1q Subtype Switching
Score: 0.44
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: associated_with
CD47 Gene
gene · KG edge: activates
C3 — Complement Component 3
gene · KG edge: regulates

Knowledge Graph (12 edges)

C1R co_discussed C1S
C1R activates CD47
C1R regulates ITGAM
C1R regulates MERTK
C1R activates SIRPA
C1R regulates SIRPA
C1R regulates C1QC
C1R regulates C1S
C1R regulates C1QA
C1R regulates CD47