gene 975 words KG: ITGAM 2026-03-21
kind:genesection:genesstate:published
Contents

ITGAM Gene

🧬 Gene Info
Gene SymbolITGAM
Protein TypeReceptor
Functionis a multifunctional immune receptor that binds complement fragment iC3b, ICAM-family ligands, fibrinogen, and damage-associated molecular patterns.
Amino Acids1153 aa
PathwaysComplement
Ensembl IDENSG00000169896
GeneCardsITGAM
Human Protein AtlasITGAM
Associated DiseasesALS, Aging, Alzheimer, Parkinson's disease, Senescence
InteractionsTNF, CXCL2, CD14, PPARG, JUN, TLR2
KG Connections204 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
CD14 — CD14 Molecule
gene · KG edge: activates

Knowledge Graph (12 edges)

ITGAM activates TNF
ITGAM activates CXCL2
ITGAM activates CD14
ITGAM activates PPARG
ITGAM activates JUN
ITGAM activates TLR2
ITGAM activates NFKBIA
ITGAM activates MRC1
ITGAM activates CD47
ITGAM co_discussed MERTK