Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CLN5 |
| Aliases | Page for CLN5 Gene |
| Chromosome | 13q22.3 |
| Protein Family | CLN5 family |
| Function | It contains a signal peptide for secretion and is targeted to lysosomes via mannose-6-phosphate-independent pathways[2]. |
| Molecular Weight | 48 kDa |
| Amino Acids | 407 aa |
| Exons | 4 |
| Pathways | Autophagy |
| UniProt ID | Q9NWW5 |
| NCBI Gene ID | 1203 |
| Ensembl ID | ENSG00000157540 |
| OMIM | 608096 |
| GeneCards | CLN5 |
| Human Protein Atlas | CLN5 |
| Associated Diseases | neurodegeneration |
| Interactions | CR1, PARP1, SIGLEC9, SIRPA, TPP1, VEGFB |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CLN5["CLN5"]
Ms{"Ms"}
CLN5 -->|"regulates"| Ms
Als{"Als"}
CLN5 -->|"expressed_in"| Als
CTSD["CTSD"]
CLN5 -->|"regulates"| CTSD
MICROTUBULES["MICROTUBULES"]
CLN5 -->|"regulates"| MICROTUBULES
ATG9["ATG9"]
CLN5 -->|"associated_with"| ATG9
AUTOPHAGY["AUTOPHAGY"]
CLN5 -->|"activates"| AUTOPHAGY
Autophagy(["Autophagy"])
CLN5 -->|"activates"| Autophagy
Exocytosis(["Exocytosis"])
CLN5 -->|"associated_with"| Exocytosis
LYST["LYST"]
LYST -->|"regulates"| CLN5
ATG1["ATG1"]
ATG1 -->|"associated_with"| CLN5
AND["AND"]
AND -->|"regulates"| CLN5
ATG5["ATG5"]
ATG5 -->|"associated_with"| CLN5
neurodegeneration["neurodegeneration"]
CLN5 -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| SIRPA | interacts_with | gene | 0.70 |
| Ms | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| CTSD | regulates | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| SIGLEC9 | interacts_with | gene | 0.60 |
| TPP1 | interacts_with | gene | 0.60 |
| VEGFB | interacts_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| SIRPA | associated_with | gene | 0.60 |
| TMEM106B | associated_with | gene | 0.60 |
| CTSH | interacts_with | gene | 0.60 |
| TMEM106B | interacts_with | gene | 0.60 |
| MICROTUBULES | regulates | gene | 0.60 |
| ATG9 | associated_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| ALS | interacts_with | disease | 0.60 |
| multiple sclerosis | interacts_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||