gene 615 words KG: CCL20 2026-03-17
kind:genesection:genesstate:published
Contents

CCL20 Gene

🧬 Gene Info
Gene SymbolCCL20
Chromosome2q36.3
Protein TypeChemokine
FunctionCCL20 has distinct functions in immune and nervous systems:
Primary ExpressionCCR6 is expressed on Th17 cells, regulatory T cells, B cells, and dendritic cells
Molecular Weight~8 kDa
PathwaysPI3K, MAPK
NCBI Gene ID6384
GeneCardsCCL20
Human Protein AtlasCCL20
Protein ClassChemokine
Cell TypeExpression Level
[Neurons](/entities/neurons)Low-Moderate
[Astrocytes](/entities/astrocytes)High
MicrogliaModerate-High
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/CompoundsIRN
InteractionsTLR4, MMP9, IL6, C1QA, LRP1, CXCL10
KG Connections156 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: associated_with
CEBPB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CCL20 activates TLR4
CCL20 activates MMP9
CCL20 activates IL6
CCL20 regulates STAT3
CCL20 regulates CX3CL1
CCL20 regulates CXCL10
CCL20 activates C1QA
CCL20 activates LRP1
CCL20 associated_with CD38
CCL20 associated_with FOXP3