gene

CCR6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections
0Hypotheses
0Analyses
19Outgoing
13Incoming

Summary

CCR6 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, implicated in. Associated with ALS, Als. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCCR6
Chromosome6q27
Protein TypeReceptor
Functionencodes a G protein-coupled receptor for CCL20 (MIP-3α/MIP-3a), also known as exodus-1 or LARC (Liver and Activation-Regulated Chemokine).
Primary Expressionrheumatoid synovium
Amino Acids374 aa
Exons4
Ensembl IDENSG00000112486
GeneCardsCCR6
Human Protein AtlasCCR6
N-terminal extracellular domainLigand binding
Seven transmembrane domainsGPCR core
Three extracellular loopsLigand interaction
Three intracellular loopsSignal transduction
C-terminal intracellular tailG protein coupling and desensitization
Associated Diseasesneurodegeneration
InteractionsCD163, APOE, IL6, ERK1, FUS, CD4
KG Connections32 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

CCR6

gene · 870 words

CCL20 Gene

gene · 615 words

Genes

index · 271 words

Pathway Diagram

graph TD
    CCR6["<b>CCR6</b>"]
    Als{"Als"}
    CCR6 -->|"expressed in"| Als
    ALS{"ALS"}
    CCR6 -->|"expressed in"| ALS
    CD163["CD163"]
    CCR6 -->|"activates"| CD163
    AND["AND"]
    CCR6 -->|"expressed in"| AND
    B_Cell["B Cell"]
    CCR6 -->|"expressed in"| B_Cell
    neurodegeneration["neurodegeneration"]
    CCR6 -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"activates"| CCR6
    LDLR["LDLR"]
    LDLR -->|"activates"| CCR6
    FOXP3["FOXP3"]
    FOXP3 -->|"activates"| CCR6
    CD8["CD8"]
    CD8 -->|"activates"| CCR6
    APOE["APOE"]
    APOE -->|"activates"| CCR6
    GZMA["GZMA"]
    GZMA -->|"activates"| CCR6
    style CCR6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Memory B Cell Precursorbiomarker_forcell_type0.95
Germinal Center Light Zoneexpressed_incell_type0.90
Memory B Cell Differentiationmediatesprocess0.85
Memory B Cell Phenotyperegulatesphenotype0.85
Quiescent Statepromotesphenotype0.75

Incoming (13)

SourceRelationTypeStr
CD4activatesgene0.60
LDLRactivatesgene0.60
FOXP3activatesgene0.60
CD8activatesgene0.60
APOEactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found