gene 1,969 words KG: CHUK 2026-03-28
kind:genesection:genesstate:published
Contents

CHUK — IKK Alpha (IκB Kinase Alpha)

🧬 Gene Info
Gene SymbolCHUK
Full NameIKK Alpha (IκB Kinase Alpha)
Chromosome10q24.31
Protein TypeKinase
Functionis a critical serine/threonine protein kinase that plays a central role in the NF-κB signaling pathway.
Molecular Weight85 kDa
Amino Acids745 aa
Exons21
PathwaysNF-κB signaling
UniProt ID[O15111](https://www.uniprot.org/uniprot/O15111)
Ensembl IDENSG00000028137
OMIM600655
GeneCardsCHUK
Human Protein AtlasCHUK
Histone H3At Ser10, linking NF-κB to chromatin remodeling
Associated Diseasesneurodegeneration
InteractionsGAIN, MTOR, IKBKB, PRDX6, MAPK14, BECN1
KG Connections94 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (11)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: phosphorylates
Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: therapeutic_target
IL1B Gene - Interleukin 1 Beta
gene · KG edge: activates
IKBKB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CHUK inhibits MPXV
CHUK inhibits GAIN
CHUK inhibits MTOR
CHUK inhibits IKBKB
CHUK activates PRDX6
CHUK activates MAPK14
CHUK activates BECN1
CHUK activates TNF
CHUK activates ECSIT
CHUK activates MAP3K7