ECSIT

Understanding Entity Pages

This page aggregates everything SciDEX knows about ECSIT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ECSIT gene encodes a critical adaptor protein in innate immune signaling and mitochondrial electron transport chain assembly, with essential roles in neuroinflammation and mitochondrial function in neurodegenerative diseases.

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graph TD
    ECSIT["<b>ECSIT</b>"]
    Cancer{"Cancer"}
    ECSIT -->|"activates"| Cancer
    Als{"Als"}
    ECSIT -->|"activates"| Als
    Ms{"Ms"}
    ECSIT -->|"activates"| Ms
    MAP3K7["MAP3K7"]
    ECSIT -->|"activates"| MAP3K7
    TLR4["TLR4"]
    ECSIT -->|"activates"| TLR4
    RELA["RELA"]
    ECSIT -->|"activates"| RELA
    TAK1["TAK1"]
    ECSIT -->|"activates"| TAK1
    IKBKB["IKBKB"]
    ECSIT -->|"activates"| IKBKB
    IL6["IL6"]
    ECSIT -->|"activates"| IL6
    NFKB["NFKB"]
    ECSIT -->|"activates"| NFKB
    LC3["LC3"]
    ECSIT -->|"activates"| LC3
    Nf_Kb(["Nf-Kb"])
    ECSIT -->|"activates"| Nf_Kb
    P38["P38"]
    P38 -->|"activates"| ECSIT
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"activates"| ECSIT
    IL1B["IL1B"]
    IL1B -->|"activates"| ECSIT
    PRDX1["PRDX1"]
    PRDX1 -->|"activates"| ECSIT
    TRAF6["TRAF6"]
    TRAF6 -->|"activates"| ECSIT
    CHUK["CHUK"]
    CHUK -->|"activates"| ECSIT
    PRDX6["PRDX6"]
    PRDX6 -->|"activates"| ECSIT
    MAPK14["MAPK14"]
    MAPK14 -->|"activates"| ECSIT
    BECN1["BECN1"]
    BECN1 -->|"activates"| ECSIT
    TNF["TNF"]
    TNF -->|"activates"| ECSIT
    TLR4 -->|"activates"| ECSIT
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| ECSIT
    style ECSIT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0