concept

DSDNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DSDNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

231Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

Summary

DSDNA is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with Als, Alzheimer, Autoimmune. Connected to 168 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DSDNA
Key Genes/Proteins	STING, CGAS, DNA, CGAS-STING, GENES, IRF3
Related Diseases	Cancer, Als, Tumor
Related Pathways	Pyroptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DSDNA["DSDNA"]
    DSDNA -->|"activates"| cGAS["cGAS"]
    DSDNA -->|"activates"| Cancer["Cancer"]
    DSDNA -->|"activates"| Als["Als"]
    DSDNA -->|"activates"| Tumor["Tumor"]
    DSDNA -->|"activates"| Ms["Ms"]
    DSDNA -->|"activates"| Ischemia["Ischemia"]
    DSDNA -->|"activates"| Cardiac["Cardiac"]
    DSDNA -->|"activates"| Inflammation["Inflammation"]
    DSDNA -->|"activates"| Neuroinflammation["Neuroinflammation"]
    DSDNA -->|"target for"| Senescence["Senescence"]
    IKBKB["IKBKB"] -->|"target for"| DSDNA
    CXCL10["CXCL10"] -->|"activates"| DSDNA
    GENES["GENES"] -->|"activates"| DSDNA
    MTOR["MTOR"] -->|"phosphorylates"| DSDNA

Outgoing (191)

Target	Relation	Type	Str
STING	activates	gene	1.00
CGAS	activates	gene	1.00
DNA	activates	gene	1.00
CGAS-STING	activates	gene	1.00
GENES	activates	gene	0.90
Cancer	activates	disease	0.85
Als	activates	disease	0.85
Tumor	activates	disease	0.75
IRF3	activates	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
PYROPTOSIS	activates	gene	0.70
Pyroptosis	activates	pathway	0.70
CGAS	inhibits	gene	0.70
STING	inhibits	gene	0.70
UBIQUITIN	inhibits	gene	0.70
IFN	activates	gene	0.70
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Cardiac	activates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Senescence	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Obesity	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	regulates	disease	0.65
Autoimmune	regulates	disease	0.65
Als	interacts_with	disease	0.65
Infection	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Lupus	associated_with	disease	0.65
Als	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Als	inhibits	disease	0.65
Tumor	implicated_in	disease	0.65
Infection	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Carcinoma	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Infection	causes	disease	0.65
Infection	activates	disease	0.65
Copd	therapeutic_target	disease	0.65
Inflammation	protects_against	disease	0.65
Als	therapeutic_target	disease	0.65
Tauopathy	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65

Incoming (40)

Source	Relation	Type	Str
IKBKB	therapeutic_target	gene	0.60
CXCL10	activates	gene	0.60
GENES	activates	gene	0.60
CHUK	associated_with	gene	0.60
MTOR	phosphorylates	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
DNA	associated_with	gene	0.60
TBK1	interacts_with	gene	0.60
TNFAIP3	inhibits	gene	0.60
NEK7	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
TBK1	activates	gene	0.60
INFLAMMATION	protects_against	gene	0.60
DNA	therapeutic_target	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TAU	activates	gene	0.60
GPX4	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CGAS	activates	gene	0.60
CGAS	associated_with	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
IFNAR1	activates	gene	0.60
CGAS	inhibits	gene	0.60
HEXB	inhibits	gene	0.60
GBA	inhibits	gene	0.60
DNA	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IKBKB	phosphorylates	gene	0.60
GAIN	phosphorylates	gene	0.60
AND	phosphorylates	gene	0.60
GAIN	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
HIPPO	phosphorylates	gene	0.60
STING	activates	gene	0.50
ferroptosis	activates	phenotype	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DSDNA

Understanding Entity Pages

Summary

Wiki Pages (20)

Mitophagy Pathway in Neurodegeneration

cGAS-STING Signaling in Parkinson's Disease

DNA Sensing Pathways in Neurodegeneration

Interferon Signaling in Neurodegeneration

cGAS-STING Pathway in Neurodegeneration

Mitophagy

cGAS-STING Inhibitors for Parkinson's Disease

Innate Immune Pattern Recognition in 4R-Tauopathies

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

Innate Immune Response in Neurodegeneration

CGAS Gene

DMC1 Gene

AIM2 Gene

cGAS-STING Inhibitor Therapy for Neurodegeneration

cGAS-STING Pathway and Autophagy in Neurodegeneration

cGAS-STING Pathway Inhibition for Chronic Neuroinflammation

AIM2 Protein — Absent in Melanoma 2

Hemiballismus