pathway

Neurotrophin Signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neurotrophin Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

1Analyses

0Outgoing

50Incoming

0Experiments

1Debates

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🔀 Pathway Info

Name	Neurotrophin Signaling
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND, BDNF, DEPRESSION, EXERCISE
Related Diseases	Alzheimer, Depression, Ms

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VGF["VGF"] -.->|"inhibits"| Neurotrophin_Signaling["Neurotrophin Signaling"]
    style VGF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DEPRESSION["DEPRESSION"] -.->|"inhibits"| Neurotrophin_Signaling["Neurotrophin Signaling"]
    style DEPRESSION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NGF["NGF"] -.->|"inhibits"| Neurotrophin_Signaling["Neurotrophin Signaling"]
    style NGF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -.->|"inhibits"| Neurotrophin_Signaling["Neurotrophin Signaling"]
    style NEURODEGENERATIVE_DISORDERS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BDNF["BDNF"] -.->|"inhibits"| Neurotrophin_Signaling["Neurotrophin Signaling"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Neurotrophin_Signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (107)

Source	Relation	Type	Str
GDNF	participates_in	gene	0.85
NGF	participates_in	gene	0.85
BDNF	participates_in	gene	0.85
microglia	active_in	cell_type	0.85
IL-10	participates_in	gene	0.85
TGF	participates_in	gene	0.85
neurodegeneration	involves	disease	0.85
neurons	active_in	cell_type	0.85
CREB	participates_in	gene	0.85
astrocytes	active_in	cell_type	0.85
Alzheimer's disease	involves	disease	0.75
PS1	participates_in	gene	0.75
ARC	participates_in	gene	0.75
PI3K	participates_in	gene	0.75
APP	participates_in	gene	0.75
CREB1	participates_in	gene	0.75
GFAP	participates_in	gene	0.75
TNF	participates_in	gene	0.75
DNA	participates_in	gene	0.75
CCN1 bicyclic peptide	activates	drug	0.70
CSF1R	participates_in	gene	0.65
APOE4	participates_in	gene	0.65
lecanemab	modulates	drug	0.65
AKT	participates_in	gene	0.65
PSD-95	participates_in	gene	0.65
HDAC	participates_in	gene	0.65
IL-6	participates_in	gene	0.65
EGR1	participates_in	gene	0.65
MAPK	participates_in	gene	0.65
stem cells	active_in	cell_type	0.65
Parkinson's disease	involves	disease	0.65
CAMK2A	participates_in	gene	0.65
HSP70	participates_in	gene	0.65
neuroinflammation	involves	disease	0.65
FOS	participates_in	gene	0.65
PARP1	participates_in	gene	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.60
VEGF	inhibits	gene	0.60
VGF	inhibits	gene	0.60
NGF	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
EAAT2	participates_in	gene	0.55
XRCC1	participates_in	gene	0.55
DNMT1	participates_in	gene	0.55
CNTF	participates_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can subcellular compartmentalization defects be measured as biomarkers in li

neuroscience | 2026-04-10 | 5 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The clinical trialist identified this as a 'fatal clinical flaw' - no validated

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning Neurotrophin Signaling in their description or question text

No additional research found

Neurotrophin Signaling

Understanding Entity Pages

Wiki Pages (3)