gene 685 words KG: CTC1 2026-03-24
kind:genesection:genesstate:published
Contents

CTC1 Gene

🧬 Gene Info
Gene SymbolCTC1
Full NameConserved Telomere Maintenance Component 1
Chromosome16p13.3
Functionencodes a essential protein component of the CST complex (CTC1-STN1-TEN1), which plays critical roles in telomere replication, telomere length maintenance, and genome stability.
Primary ExpressionUbiquitous; highest in testis, bone marrow, thymus
Amino Acids228 aa
UniProt IDQ2NKJ8
NCBI Gene ID80224
Ensembl IDENSG00000107854
OMIM613129
GeneCardsCTC1
Human Protein AtlasCTC1
Associated Diseasesneurodegeneration
InteractionsATM, TREX1, VCP, NEIL1, POT1, MRE11
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

VCP Proteostasis Modulation Therapy for ALS/FTD
idea · KG edge: interacts_with
WRN — Werner Syndrome RecQ Like Helicase
gene · KG edge: interacts_with
TREX1 — Three Prime Repair Exonuclease 1
gene · KG edge: interacts_with
SAMHD1 — SAM and HD Domain Containing Metal Dependent H
gene · KG edge: expressed_in
POT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CTC1 interacts_with ATM
CTC1 interacts_with Senescence
CTC1 interacts_with Ms
CTC1 expressed_in Complement
TREX1 interacts_with CTC1
VCP interacts_with CTC1
NEIL1 interacts_with CTC1
POLD1 expressed_in CTC1
POT1 interacts_with CTC1
MRE11 interacts_with CTC1