gene 861 words KG: NEIL1 2026-03-22
kind:genesection:genesstate:published
Contents

NEIL1 — Nei Endonuclease VIII-Like 1

🧬 Gene Info
Gene SymbolNEIL1
Full NameNei Endonuclease VIII-Like 1
Chromosome15q24.2
FunctionThe NEIL1 gene encodes a 406-amino acid DNA glycosylase that initiates base excision repair by recognizing and removing damaged bases:
Amino Acids406 aa
UniProt IDQ9Y3X0
NCBI Gene ID57478
Ensembl IDENSG00000140323
OMIM608747
GeneCardsNEIL1
Human Protein AtlasNEIL1
8-oxoguanine (8-oxoG)Oxidative
5-hydroxyuracil (5-OHU)Oxidative
Thymine glycol (Tg)Oxidative
FapyGuanine (FapyG)Oxidative
Associated Diseasesneurodegeneration
InteractionsPOLD1, POT1, MRE11, MUTYH, SAMHD1, NBS1
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Senescent Cell Mitochondrial DNA Release
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (3)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (14)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
NBS1 (NBN)
gene · KG edge: interacts_with
MUTYH Gene
gene · KG edge: interacts_with
MRE11 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

NEIL1 interacts_with POLD1
NEIL1 interacts_with POT1
NEIL1 interacts_with MRE11
NEIL1 interacts_with MUTYH
NEIL1 interacts_with SAMHD1
NEIL1 interacts_with NBS1
NEIL1 interacts_with LMNA
NEIL1 interacts_with WRN
NEIL1 interacts_with MDM2
NEIL1 interacts_with CTC1