gene 628 words KG: WRN 2026-03-21
kind:genesection:genesstate:published
Contents

WRN — Werner Syndrome RecQ Like Helicase

🧬 Gene Info
Gene SymbolWRN
Full NameWerner Syndrome RecQ Like Helicase
AliasesPage for WRN Protein
Protein TypeEnzyme
FunctionWRN is a multifunctional DNA metabolic enzyme:
Molecular Weight164 kDa
Ensembl IDENSG00000113240
GeneCardsWRN
Human Protein AtlasWRN
Base excision repair (BER)Processing of oxidative DNA damage
DNA double-strand break repairHomologous recombination and NHEJ
Telomere maintenancePrevents telomere dysfunction
Replication fork restartResolves stalled replication forks
Associated DiseasesAging, Ms, Senescence
InteractionsMDM2, CTC1, TREX1, VCP, NEIL1, POLD1
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (2)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
VCP Proteostasis Modulation Therapy for ALS/FTD
idea · KG edge: interacts_with
TREX1 — Three Prime Repair Exonuclease 1
gene · KG edge: interacts_with
SAMHD1 — SAM and HD Domain Containing Metal Dependent H
gene · KG edge: interacts_with
POT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

WRN interacts_with MDM2
WRN interacts_with CTC1
WRN regulates ATM
WRN associated_with DNA
WRN associated_with Aging
WRN therapeutic_target Ms
WRN therapeutic_target Mitophagy
WRN associated_with Senescence
WRN associated_with Ms
WRN interacts_with Complement