| Gene Symbol | MUTYH |
| Chromosome | 1p34.2 |
| Protein Type | Enzyme |
| Function | Without MUTYH, the mispaired adenine becomes fixed as a G:C to T:A mutation during replication. |
| Primary Expression | all tissues, with high expression in:
- Brain: cerebral cortex, hippocampus, cerebellum
- |
| Molecular Weight | 52 kDa |
| Amino Acids | 479 aa |
| Exons | 16 |
| Pathways | DNA Repair |
| GeneCards | MUTYH |
| Human Protein Atlas | MUTYH |
| OGG1 | Removes 8-oxoG from DNA |
| APE1 | Cleaves AP sites |
| PARP1 | Signals DNA damage |
| XRCC1 | Scaffold protein |
| Associated Diseases | Als, Cancer, neurodegeneration |
| Interactions | SAMHD1, NBS1, LMNA, WRN, MDM2, CTC1 |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |