gene 751 words KG: POT1 2026-03-24
kind:genesection:genesstate:published
Contents

POT1 Gene

🧬 Gene Info
Gene SymbolPOT1
Full NameProtection of Telomeres 1
Chromosome7q31.33
Functionis a critical component of the shelterin complex that protects telomeres from inappropriate DNA repair and regulates telomerase access.
Primary ExpressionUbiquitous, highest in testis, lymphoid tissues
Amino Acids634 aa
PathwaysTelomere
UniProt IDQ9H2R9
NCBI Gene ID54281
Ensembl IDENSG00000128513
OMIM607713
GeneCardsPOT1
Human Protein AtlasPOT1
Associated DiseasesAls, Cancer, Melanoma, Ovarian Cancer, Pancreatic Cancer
InteractionsTPP1, MRE11, MUTYH, SAMHD1, NBS1, LMNA
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
POLD1
gene · KG edge: interacts_with
NRAS Gene
gene · KG edge: activates
NF1 — Neurofibromin 1
gene · KG edge: activates
NEIL1 — Nei Endonuclease VIII-Like 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

POT1 interacts_with TPP1
POT1 interacts_with MRE11
POT1 interacts_with MUTYH
POT1 interacts_with SAMHD1
POT1 interacts_with NBS1
POT1 interacts_with LMNA
POT1 interacts_with WRN
POT1 interacts_with MDM2
POT1 interacts_with CTC1
POT1 interacts_with ATM