NBS1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NBS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NBS1 (Nibrin) is a key DNA repair gene in the MRN complex, crucial for genomic stability and neuronal survival. Mutations cause Nijmegen Breakage Syndrome.

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graph TD
    NBS1["<b>NBS1</b>"]
    Senescence{"Senescence"}
    NBS1 -->|"interacts with"| Senescence
    Ms{"Ms"}
    NBS1 -->|"interacts with"| Ms
    LMNA["LMNA"]
    NBS1 -->|"interacts with"| LMNA
    WRN["WRN"]
    NBS1 -->|"interacts with"| WRN
    MDM2["MDM2"]
    NBS1 -->|"interacts with"| MDM2
    CTC1["CTC1"]
    NBS1 -->|"interacts with"| CTC1
    ATM["ATM"]
    NBS1 -->|"interacts with"| ATM
    Complement(["Complement"])
    NBS1 -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    NBS1 -->|"implicated in"| neurodegeneration
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| NBS1
    VCP["VCP"]
    VCP -->|"interacts with"| NBS1
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| NBS1
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| NBS1
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| NBS1
    P53["P53"]
    P53 -->|"interacts with"| NBS1
    POT1["POT1"]
    POT1 -->|"interacts with"| NBS1
    MRE11["MRE11"]
    MRE11 -->|"interacts with"| NBS1
    MUTYH["MUTYH"]
    MUTYH -->|"interacts with"| NBS1
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"interacts with"| NBS1
    style NBS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0