gene 581 words KG: CTCF 2026-03-24
kind:genesection:genesstate:published
Contents

CTCF Gene

🧬 Gene Info
Gene SymbolCTCF
Full NameCCCTC-Binding Factor
Chromosome16q22.1
FunctionThe CTCF gene encodes CCCTC-Binding Factor, a highly conserved zinc finger transcription factor that is one of the most important architectural proteins in the mammalian genome.
Primary Expressionboth excitatory and inhibitory neurons throughout development and in adulthood
Molecular Weight83 kDa
PathwaysAutophagy, Cell Cycle, Epigenetic, Inflammasome, Neurogenesis
UniProt IDP49711
NCBI Gene ID1065
Ensembl IDENSG00000102974
OMIM114167
GeneCardsCTCF
Human Protein AtlasCTCF
Associated DiseasesCancer
InteractionsPARP1, EP300, IGF2BP2, NADH, DNA, BNIP3L
KG Connections78 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.66
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: inhibits
CSF1R — Colony Stimulating Factor 1 Receptor
gene · KG edge: therapeutic_target
csf1
gene · KG edge: therapeutic_target
BNIP3L — BCL2 Interacting Protein 3 Like (NIX)
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CTCF activates PARP1
CTCF interacts_with EP300
CTCF activates IGF2BP2
CTCF therapeutic_target CSF1R
CTCF associated_with SMPD1
CTCF associated_with BCL2
CTCF associated_with LC3
CTCF associated_with AKT
CTCF regulates E2F3
CTCF regulates Rb