gene 1,653 words KG: CSF1
Contents

CSF1 Gene

🧬 Gene Info
Gene SymbolCSF1
Chromosome1p13.3
Functionis a disulfide-bonded homodimer of approximately 60 kDa.
Primary Expressionneurons[@wang2018]
Molecular Weight60 kDa
Amino Acids554 aa
Exons11
PathwaysPI3K, MAPK
Ensembl IDENSG00000184371
GeneCardsCSF1
Human Protein AtlasCSF1
Isoform 1 (canonical)554 amino acids, secreted soluble protein
Isoform 2Truncated, membrane-bound form
Isoform 3Alternative start site variant
N-terminal signal peptideDirects secretion
Associated DiseasesMelanoma, Tumor, multiple sclerosis
InteractionsBAX, DDX58, STAT1, BNIP3L, NEAT1, PPARG
KG Connections161 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (16)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with

Knowledge Graph (12 edges)

CSF1 activates BAX
CSF1 activates DDX58
CSF1 activates STAT1
CSF1 activates BNIP3L
CSF1 activates NEAT1
CSF1 activates PPARG
CSF1 activates CDK2
CSF1 therapeutic_target CTCF
CSF1 activates EP300
CSF1 activates IGF2BP2