gene 778 words KG: DCTN5 2026-03-20
kind:genesection:genesstate:published
Contents

DCTN5 Gene

🧬 Gene Info
Gene SymbolDCTN5
Full NameDCTN5
Chromosome16p12.2
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionSpinal Cord
PathwaysMitophagy, Alpha-Synuclein
NCBI Gene IDSearch NCBI
GeneCardsDCTN5
Human Protein AtlasDCTN5
Associated DiseasesALS, Neurodegeneration, Parkinson
InteractionsDCAF17, UBIQUITIN, PINK1, H2AX, P62, SNCA
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

p62 - Sequestosome 1 (SQSTM1)
protein · KG edge: causes
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: inhibits
H2AX Gene
gene · KG edge: inhibits
DCAF17 Gene - DDB1 and CUL4 Associated Factor 17
gene · KG edge: activates

Knowledge Graph (12 edges)

DCTN5 associated_with TREM2
DCTN5 associated_with OxPC
DCTN5 associated_with STRRIDE
DCTN5 activates DCAF17
DCTN5 inhibits UBIQUITIN
DCTN5 inhibits PINK1
DCTN5 inhibits H2AX
DCTN5 inhibits P62
DCTN5 activates SNCA
DCTN5 activates DAPK1