H2AX

Understanding Entity Pages

This page aggregates everything SciDEX knows about H2AX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

H2A.X histone variant involved in DNA damage response, neurodegenerative diseases, and cancer biology

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graph TD
    H2AX["<b>H2AX</b>"]
    Als{"Als"}
    H2AX -->|"activates"| Als
    Ms{"Ms"}
    H2AX -->|"expressed in"| Ms
    Glioblastoma{"Glioblastoma"}
    H2AX -->|"expressed in"| Glioblastoma
    Aging{"Aging"}
    H2AX -->|"therapeutic target"| Aging
    H2AX -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    H2AX -->|"therapeutic target"| Cancer
    OCLN["OCLN"]
    H2AX -->|"regulates"| OCLN
    RAC1["RAC1"]
    H2AX -->|"regulates"| RAC1
    PIK3C3["PIK3C3"]
    H2AX -->|"regulates"| PIK3C3
    ATG14["ATG14"]
    H2AX -->|"associated with"| ATG14
    GJA1["GJA1"]
    H2AX -->|"associated with"| GJA1
    LAMP1["LAMP1"]
    H2AX -->|"regulates"| LAMP1
    ACTB["ACTB"]
    ACTB -->|"associated with"| H2AX
    CDC42["CDC42"]
    CDC42 -->|"associated with"| H2AX
    CASP3["CASP3"]
    CASP3 -->|"associated with"| H2AX
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"regulates"| H2AX
    TUBB3["TUBB3"]
    TUBB3 -->|"regulates"| H2AX
    STK11["STK11"]
    STK11 -->|"regulates"| H2AX
    VIM["VIM"]
    VIM -->|"regulates"| H2AX
    BECN1["BECN1"]
    BECN1 -->|"associated with"| H2AX
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| H2AX
    GAPDH["GAPDH"]
    GAPDH -->|"associated with"| H2AX
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"regulates"| H2AX
    MAP3K5["MAP3K5"]
    MAP3K5 -->|"regulates"| H2AX
    style H2AX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0