gene 649 words KG: DLC1 2026-03-24
kind:genesection:genesstate:published
Contents

DLC1 Gene - Deleted in Liver Cancer 1

🧬 Gene Info
Gene SymbolDLC1
AliasesPage for DLC1 Gene
Chromosome8p22.
FunctionDLC1 (Deleted in Liver Cancer 1) is a GTPase-activating protein (GAP) that specifically inactivates Rho family GTPases, primarily RhoA, Rac1, and Cdc42.
Primary Expressiondopaminergic neurons where it may protect against oxidative stress
PathwaysApoptosis, Wnt, Mapk
Ensembl IDENSG00000121667
GeneCardsDLC1
Human Protein AtlasDLC1
Associated Diseasesneurodegeneration
InteractionsKCNH1, NCAM1, RGS1, RAB27A, TLR4, TNC
KG Connections25 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: associated_with
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: inhibits
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
TNC Gene
gene · KG edge: inhibits
RGS1 — Regulator of G Protein Signaling 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

DLC1 inhibits KCNH1
DLC1 inhibits NCAM1
DLC1 inhibits RGS1
DLC1 inhibits RAB27A
DLC1 associated_with COL4A1
DLC1 inhibits Carcinoma
DLC1 inhibits Ms
DLC1 inhibits Cancer
DLC1 inhibits Tumor
DLC1 inhibits Apoptosis