Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF10 encodes a critical growth factor that promotes neural progenitor cell proliferation, neurogenesis, and brain development, with roles in neural regeneration, neuroprotection, and potential therapeutic applications in neurodegenerative diseases.
| Gene Symbol | FGF10 |
| Full Name | Fibroblast Growth Factor 10 |
| Chromosome | 5p12 |
| Function | encodes a critical member of the fibroblast growth factor family that plays essential roles in embryonic development, tissue morphogenesis, and cellular proliferation. |
| Primary Expression | epithelial and neuronal tissues[@kumar1998] |
| Molecular Weight | 23.4 kDa |
| Amino Acids | 208 aa |
| UniProt ID | O15520 |
| NCBI Gene ID | 2255 |
| Ensembl ID | ENSG00000164283 |
| OMIM | 602115 |
| GeneCards | FGF10 |
| Human Protein Atlas | FGF10 |
| N-terminal signal peptide | Directs secretion |
| FGF core domain | Conserved 120-amino acid core |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | DLC1, KCNH1, NCAM1, RGS1, RAB27A, COL4A1 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FGF10["<b>FGF10</b>"]
Carcinoma{"Carcinoma"}
FGF10 -->|"inhibits"| Carcinoma
Ms{"Ms"}
FGF10 -->|"inhibits"| Ms
Cancer{"Cancer"}
FGF10 -->|"inhibits"| Cancer
Tumor{"Tumor"}
FGF10 -->|"inhibits"| Tumor
DLC1["DLC1"]
FGF10 -->|"inhibits"| DLC1
KCNH1["KCNH1"]
FGF10 -->|"inhibits"| KCNH1
NCAM1["NCAM1"]
FGF10 -->|"inhibits"| NCAM1
RGS1["RGS1"]
FGF10 -->|"inhibits"| RGS1
RAB27A["RAB27A"]
FGF10 -->|"inhibits"| RAB27A
COL4A1["COL4A1"]
FGF10 -->|"inhibits"| COL4A1
Apoptosis(["Apoptosis"])
FGF10 -->|"inhibits"| Apoptosis
Wnt(["Wnt"])
FGF10 -->|"inhibits"| Wnt
CDKN2A["CDKN2A"]
CDKN2A -->|"inhibits"| FGF10
TLR4["TLR4"]
TLR4 -->|"inhibits"| FGF10
CANCER["CANCER"]
CANCER -->|"inhibits"| FGF10
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| FGF10
TNC["TNC"]
TNC -->|"inhibits"| FGF10
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| FGF10
PAK1["PAK1"]
PAK1 -->|"inhibits"| FGF10
WNT7A["WNT7A"]
WNT7A -->|"inhibits"| FGF10
LZTS1["LZTS1"]
LZTS1 -->|"inhibits"| FGF10
DCC["DCC"]
DCC -->|"inhibits"| FGF10
KCNK2["KCNK2"]
KCNK2 -->|"inhibits"| FGF10
CD44["CD44"]
CD44 -->|"inhibits"| FGF10
style FGF10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| DLC1 | inhibits | gene | 0.60 |
| KCNH1 | inhibits | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| RGS1 | inhibits | gene | 0.60 |
| RAB27A | inhibits | gene | 0.60 |
| COL4A1 | inhibits | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Immune Response | inhibits | pathway | 0.60 |
| Pi3K/Akt | inhibits | pathway | 0.60 |
| Macrophage | inhibits | cell_type | 0.60 |
| Monocyte | inhibits | cell_type | 0.60 |
| Fibroblast | associated_with | cell_type | 0.60 |
| Dendritic Cell | inhibits | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CDKN2A | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | inhibits | gene | 0.60 |
| LZTS1 | inhibits | gene | 0.60 |
| DCC | inhibits | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| IRF7 | inhibits | gene | 0.60 |
| ISG15 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| IL-4 | inhibits | gene | 0.60 |
| IL-13 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||