gene

FGF10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections
0Hypotheses
0Analyses
21Outgoing
17Incoming

Summary

FGF10 encodes a critical growth factor that promotes neural progenitor cell proliferation, neurogenesis, and brain development, with roles in neural regeneration, neuroprotection, and potential therapeutic applications in neurodegenerative diseases.

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🧬 Gene Info
Gene SymbolFGF10
Full NameFibroblast Growth Factor 10
Chromosome5p12
Functionencodes a critical member of the fibroblast growth factor family that plays essential roles in embryonic development, tissue morphogenesis, and cellular proliferation.
Primary Expressionepithelial and neuronal tissues[@kumar1998]
Molecular Weight23.4 kDa
Amino Acids208 aa
UniProt IDO15520
NCBI Gene ID2255
Ensembl IDENSG00000164283
OMIM602115
GeneCardsFGF10
Human Protein AtlasFGF10
N-terminal signal peptideDirects secretion
FGF core domainConserved 120-amino acid core
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsDLC1, KCNH1, NCAM1, RGS1, RAB27A, COL4A1
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FGF10 — AlphaFold O15520 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

FGF10 — Fibroblast Growth Factor 10

gene · 3796 words

DCC

gene · 2541 words

TBX1 — T-Box Transcription Factor 1

gene · 2492 words

FGFR3 - Fibroblast Growth Factor Receptor 3

gene · 1352 words

FGF19 — Fibroblast Growth Factor 19

gene · 1001 words

FGF7 Protein

protein · 619 words

Pathway Diagram

graph TD
    FGF10["<b>FGF10</b>"]
    Carcinoma{"Carcinoma"}
    FGF10 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    FGF10 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    FGF10 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    FGF10 -->|"inhibits"| Tumor
    DLC1["DLC1"]
    FGF10 -->|"inhibits"| DLC1
    KCNH1["KCNH1"]
    FGF10 -->|"inhibits"| KCNH1
    NCAM1["NCAM1"]
    FGF10 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    FGF10 -->|"inhibits"| RGS1
    RAB27A["RAB27A"]
    FGF10 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    FGF10 -->|"inhibits"| COL4A1
    Apoptosis(["Apoptosis"])
    FGF10 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    FGF10 -->|"inhibits"| Wnt
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| FGF10
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| FGF10
    CANCER["CANCER"]
    CANCER -->|"inhibits"| FGF10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| FGF10
    TNC["TNC"]
    TNC -->|"inhibits"| FGF10
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| FGF10
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| FGF10
    WNT7A["WNT7A"]
    WNT7A -->|"inhibits"| FGF10
    LZTS1["LZTS1"]
    LZTS1 -->|"inhibits"| FGF10
    DCC["DCC"]
    DCC -->|"inhibits"| FGF10
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| FGF10
    CD44["CD44"]
    CD44 -->|"inhibits"| FGF10
    style FGF10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

TargetRelationTypeStr
Carcinomainhibitsdisease0.65
Msinhibitsdisease0.65
Cancerinhibitsdisease0.65
Tumorinhibitsdisease0.65
Alsinhibitsdisease0.65

Incoming (17)

SourceRelationTypeStr
CDKN2Ainhibitsgene0.60
TLR4inhibitsgene0.60
TNCinhibitsgene0.60
NTRK2inhibitsgene0.60
PAK1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found