gene 736 words KG: TNC 2026-03-24
kind:genesection:genesstate:published
Contents

TNC Gene

🧬 Gene Info
Gene SymbolTNC
Full NameTenascin C
Chromosome9
FunctionThe TNC gene encodes Tenascin C, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum.
Primary Expressionvarious brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum
PathwaysInflammasome, Nf-Κb
UniProt IDP24821
Ensembl IDENSG00000052850
OMIM187380
GeneCardsTNC
Human Protein AtlasTNC
Genomic Location9q33.1
ApproachStatus
Small molecule inhibitorsPreclinical
Monoclonal antibodiesPreclinical
Associated DiseasesAls, Entheseal new bone formation, Extracellular matrix adhesion force, Fibrosis, Liver fibrosis
Known Drugs/Compoundsmetformin
InteractionsPAK1, WNT7A, LZTS1, DCC, KCNK2, CD44
KG Connections75 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: activates
SYK Gene
gene · KG edge: regulates
PPARG — Peroxisome Proliferator-Activated Receptor Gamm
gene · KG edge: regulates
LDLR Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TNC provides_data_for ds-83b31ef18d49
TNC associated_with NTRK2
TNC inhibits PAK1
TNC inhibits WNT7A
TNC inhibits LZTS1
TNC inhibits DCC
TNC inhibits KCNK2
TNC inhibits CD44
TNC inhibits FGF10
TNC inhibits DLC1