gene

KCNH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections
0Hypotheses
0Analyses
11Outgoing
14Incoming

Summary

KCNH1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in, associated with. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolKCNH1
Full NamePotassium Voltage-Gated Channel Subfamily H Member 1
Chromosome1p36.33
Protein TypeChannel
Functionis a voltage-gated potassium channel with unique properties in neuronal excitability, cell proliferation, and synaptic transmission.
Amino Acids958 aa
UniProt IDQ14721
NCBI Gene ID3756
Ensembl IDENSG00000128408
OMIM603305
GeneCardsKCNH1
Human Protein AtlasKCNH1
ApproachTarget
KCNH1 blockersAntiepileptic
KCNH1 openersMemory enhancement
Associated Diseasesneurodegeneration
InteractionsNCAM1, RAB27A, COL4A1, CDKN2A, TLR4, TNC
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KCNH1 — AlphaFold Q14721 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

KCNH1 Gene

gene · 862 words

DCC

gene · 2541 words

KCNH6 (Potassium Voltage-Gated Channel Subfamily H Member 6)

gene · 2029 words

KCNH7 Gene

gene · 1986 words

KCNH5 Gene

gene · 1161 words

KCNH6 Protein (ERG2 Potassium Channel)

protein · 651 words

Pathway Diagram

graph TD
    KCNH1["<b>KCNH1</b>"]
    Carcinoma{"Carcinoma"}
    KCNH1 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    KCNH1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    KCNH1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    KCNH1 -->|"inhibits"| Tumor
    NCAM1["NCAM1"]
    KCNH1 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    KCNH1 -->|"associated with"| RGS1
    RAB27A["RAB27A"]
    KCNH1 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    KCNH1 -->|"inhibits"| COL4A1
    Apoptosis(["Apoptosis"])
    KCNH1 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    KCNH1 -->|"inhibits"| Wnt
    Mapk(["Mapk"])
    KCNH1 -->|"inhibits"| Mapk
    neurodegeneration["neurodegeneration"]
    KCNH1 -->|"implicated in"| neurodegeneration
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| KCNH1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| KCNH1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| KCNH1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| KCNH1
    TNC["TNC"]
    TNC -->|"inhibits"| KCNH1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| KCNH1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| KCNH1
    WNT7A["WNT7A"]
    WNT7A -->|"inhibits"| KCNH1
    LZTS1["LZTS1"]
    LZTS1 -->|"inhibits"| KCNH1
    DCC["DCC"]
    DCC -->|"inhibits"| KCNH1
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| KCNH1
    CD44["CD44"]
    CD44 -->|"inhibits"| KCNH1
    style KCNH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Carcinomainhibitsdisease0.65
Msinhibitsdisease0.65
Cancerinhibitsdisease0.65
Tumorinhibitsdisease0.65
NCAM1inhibitsgene0.60

Incoming (14)

SourceRelationTypeStr
CDKN2Ainhibitsgene0.60
TLR4inhibitsgene0.60
TNCinhibitsgene0.60
NTRK2inhibitsgene0.60
PAK1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found