Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNH1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in, associated with. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | KCNH1 |
| Full Name | Potassium Voltage-Gated Channel Subfamily H Member 1 |
| Chromosome | 1p36.33 |
| Protein Type | Channel |
| Function | is a voltage-gated potassium channel with unique properties in neuronal excitability, cell proliferation, and synaptic transmission. |
| Amino Acids | 958 aa |
| UniProt ID | Q14721 |
| NCBI Gene ID | 3756 |
| Ensembl ID | ENSG00000128408 |
| OMIM | 603305 |
| GeneCards | KCNH1 |
| Human Protein Atlas | KCNH1 |
| Approach | Target |
| KCNH1 blockers | Antiepileptic |
| KCNH1 openers | Memory enhancement |
| Associated Diseases | neurodegeneration |
| Interactions | NCAM1, RAB27A, COL4A1, CDKN2A, TLR4, TNC |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNH1["<b>KCNH1</b>"]
Carcinoma{"Carcinoma"}
KCNH1 -->|"inhibits"| Carcinoma
Ms{"Ms"}
KCNH1 -->|"inhibits"| Ms
Cancer{"Cancer"}
KCNH1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
KCNH1 -->|"inhibits"| Tumor
NCAM1["NCAM1"]
KCNH1 -->|"inhibits"| NCAM1
RGS1["RGS1"]
KCNH1 -->|"associated with"| RGS1
RAB27A["RAB27A"]
KCNH1 -->|"inhibits"| RAB27A
COL4A1["COL4A1"]
KCNH1 -->|"inhibits"| COL4A1
Apoptosis(["Apoptosis"])
KCNH1 -->|"inhibits"| Apoptosis
Wnt(["Wnt"])
KCNH1 -->|"inhibits"| Wnt
Mapk(["Mapk"])
KCNH1 -->|"inhibits"| Mapk
neurodegeneration["neurodegeneration"]
KCNH1 -->|"implicated in"| neurodegeneration
CDKN2A["CDKN2A"]
CDKN2A -->|"inhibits"| KCNH1
TLR4["TLR4"]
TLR4 -->|"inhibits"| KCNH1
CANCER["CANCER"]
CANCER -->|"inhibits"| KCNH1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| KCNH1
TNC["TNC"]
TNC -->|"inhibits"| KCNH1
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| KCNH1
PAK1["PAK1"]
PAK1 -->|"inhibits"| KCNH1
WNT7A["WNT7A"]
WNT7A -->|"inhibits"| KCNH1
LZTS1["LZTS1"]
LZTS1 -->|"inhibits"| KCNH1
DCC["DCC"]
DCC -->|"inhibits"| KCNH1
KCNK2["KCNK2"]
KCNK2 -->|"inhibits"| KCNH1
CD44["CD44"]
CD44 -->|"inhibits"| KCNH1
style KCNH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| CDKN2A | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | inhibits | gene | 0.60 |
| LZTS1 | inhibits | gene | 0.60 |
| DCC | inhibits | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| DLC1 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||