gene 1,339 words KG: DMT1 2026-03-26
kind:genesection:genesstate:published
Contents

DMT1 Gene

🧬 Gene Info
Gene SymbolDMT1 (SLC11A2)
AliasesSLC11A2, Divalent Metal Transporter 1
Chromosome12q14.2
Protein TypeTransporter
FunctionDMT1 is the primary transporter for non-heme iron uptake
Subcellular LocalizationPlasma membrane, Endosomes, Lysosomes
Molecular Weight~54 kDa
Amino Acids495 aa
PathwaysFerroptosis, Inflammasome, Nf-Κb, Oxidative Stress, Synaptic Plasticity
UniProt IDQ8IWU6
NCBI Gene ID6554
Ensembl IDENSG00000104691
OMIM604187, 600042
Alternative NamesDCT1, NRAMP2, Divalent Cation Transporter 1
Protein Length495 amino acids
Associated DiseasesParkinson's disease
Known Drugs/CompoundsDietary Iron, Dietary iron
InteractionsGPX4, KEAP1, NRF2, JNK, P62, CYBB
KG Connections142 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (9)

Ferroportin (SLC40A1)
protein · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
CYBB — Cytochrome b-245, Beta Polypeptide
gene · KG edge: activates

Knowledge Graph (12 edges)

DMT1 associated_with FERROPORTIN
DMT1 mediates Iron Uptake
DMT1 involved_in IRON METABOLISM
DMT1 activates GPX4
DMT1 associated_with TFR1
DMT1 activates KEAP1
DMT1 activates NRF2
DMT1 transports FERROPORTIN
DMT1 inhibits JNK
DMT1 expressed_in FTH1