gene 636 words KG: NCOA4 2026-03-24
kind:genesection:genesstate:published
Contents

NCOA4 Gene

🧬 Gene Info
Gene SymbolNCOA4
Full NameNuclear Receptor Coactivator 4
Chromosome10q11.23
Protein TypeReceptor
FunctionNCOA4 performs two major functions in the cell:
Primary Expressionhuman tissues: - Brain: Moderate expression in cortex, hippocampus, basal ganglia - Highe
Molecular Weight70 kDa
PathwaysAkt, Autophagy, FERRITINOPHAGY, Ferroptosis, Iron Metabolism
UniProt IDQ9UBR1
NCBI Gene ID8031
Ensembl IDENSG00000135333
OMIM605161
GeneCardsNCOA4
Human Protein AtlasNCOA4
Associated DiseasesCarcinoma, Cardiovascular, Hepatocellular Carcinoma, Lactation Dysfunction, Parkinson, Tumor
Known Drugs/CompoundsSalidroside, rapamycin
InteractionsGPX4, ATG7, ATG4B, ATG3, SLC7A11, P62
KG Connections458 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
ATM Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates
ATG4B — Autophagy Related 4B Cysteine Peptidase
gene · KG edge: activates

Knowledge Graph (12 edges)

NCOA4 inhibits GPX4
NCOA4 associated_with ARNTL
NCOA4 associated_with CGAS
NCOA4 associated_with SLC7A11
NCOA4 associated_with TMEM173
NCOA4 associated_with FANCD2
NCOA4 associated_with STING1
NCOA4 associated_with TFAM
NCOA4 associated_with POLG
NCOA4 associated_with ATM