Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATF2 |
| Full Name | Activating Transcription Factor 2 |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 75 kDa |
| Pathways | Autophagy, Neurogenesis, Epigenetic, Mitochondrial Function, Pi3K/Akt |
| GeneCards | ATF2 |
| Human Protein Atlas | ATF2 |
| bZIP domain | Basic region for DNA binding, leucine zipper for dimerization |
| DNA-binding specificity | Recognizes ATF/CRE (TGACGTCA) and AP-1 (TGACTCA) sites |
| Protein interaction domains | Binds to CBP/p300 coactivators |
| Cell survival | BCL-2, IAPs |
| Stress response | HSP70, GADD45 |
| Inflammation | IL-6, IL-8, TNF-α |
| synaptic plasticity | CREB-dependent genes |
| Associated Diseases | Als, Ataxia, Dystonia, Huntington, Ms, Parkinson |
| Known Drugs/Compounds | metformin |
| Interactions | SQSTM1, CSF1, BNIP3L, NEAT1, PPARG, CDK2 |
| KG Connections | 87 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATF2["ATF2"] -->|"regulates"| PIEZO1["PIEZO1"]
style PIEZO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Tumor["Tumor"]
style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Cancer["Cancer"]
style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Als["Als"]
style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Ms["Ms"]
style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Aging["Aging"]
style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATF2["ATF2"] -->|"activates"| Inflammation["Inflammation"]
style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
MAPK["MAPK"] -->|"upstream of"| ATF2["ATF2"]
style MAPK fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
AGING["AGING"] -->|"activates"| ATF2["ATF2"]
style AGING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
SOX2["SOX2"] -->|"activates"| ATF2["ATF2"]
style SOX2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ATF2["ATF2"]
style AUTOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ROS["ROS"] -->|"activates"| ATF2["ATF2"]
style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style ATF2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| SESN1 | upregulates | gene | 0.90 |
| SESN1 | modulates | gene | 0.90 |
| PIEZO1 | regulates | gene | 0.80 |
| Tumor | activates | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| CANCER | activates | gene | 0.70 |
| Ms | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Gastric Cancer | activates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Dystonia | associated_with | disease | 0.65 |
| Huntington | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| SQSTM1 | activates | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| BRG1 | regulates | gene | 0.60 |
| CSF1 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| NEAT1 | activates | gene | 0.60 |
| PPARG | activates | gene | 0.60 |
| CDK2 | activates | gene | 0.60 |
| ERP57 | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| SRC | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| P38 | inhibits | gene | 0.60 |
| YY1 | associated_with | gene | 0.60 |
| USF1 | associated_with | gene | 0.60 |
| SLAMF7 | inhibits | gene | 0.60 |
| PPAR | activates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| Autophagy | expressed_in | pathway | 0.60 |
| Neurogenesis | expressed_in | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Pi3K/Akt | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPK | upstream_of | pathway | 0.90 |
| p38 mitogen-activated protein kinase | phosphorylates | protein | 0.85 |
| P38 | activates | protein | 0.85 |
| SOX2 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| BIP | regulates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| HSPH1 | activates | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| RIP1 | regulates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| metformin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||