GLA

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GLA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, contributes to. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 156 entities in the SciDEX knowledge graph.

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flowchart TD
    GLA["GLA<br/>(Alpha-galactosidase A)"]
    
    %% Autophagy pathway
    GLA --|"activates"|--> ATG12["ATG12<br/>(Autophagy protein)"]
    ATG12 --|"promotes"|--> Autophagy["Autophagy<br/>(Cellular clearance)"]
    GLA --|"associated_with"|--> BECN1["BECN1<br/>(Beclin-1)"]
    BECN1 --|"regulates"|--> Autophagy
    
    %% Calcium signaling and cellular stress
    GLA --|"activates"|--> CALCINEURIN["CALCINEURIN<br/>(Protein phosphatase)"]
    CALCINEURIN --|"regulates"|--> Calcium_Signaling["Calcium<br/>Signaling"]
    
    %% Protein quality control
    GLA --|"associated_with"|--> STUB1["STUB1<br/>(CHIP ubiquitin ligase)"]
    GLA --|"associated_with"|--> HSPB8["HSPB8<br/>(Heat shock protein)"]
    STUB1 --|"promotes"|--> Protein_Degradation["Protein<br/>Degradation"]
    HSPB8 --|"maintains"|--> Protein_Folding["Protein<br/>Folding"]
    
    %% RNA processing and neurodegeneration
    GLA --|"associated_with"|--> TARDBP["TARDBP<br/>(TDP-43)"]
    TARDBP --|"dysfunction"|--> RNA_Processing["RNA Processing<br/>Defects"]
    
    %% Metabolic regulation
    GLA --|"associated_with"|--> PPARGC1A["PPARGC1A<br/>(PGC-1alpha)"]
    PPARGC1A --|"regulates"|--> Mitochondrial_Function["Mitochondrial<br/>Function"]
    
    %% Neurodegenerative diseases
    GLA --|"activates"|--> Neurodegeneration["Neurodegeneration"]
    Neurodegeneration --|"manifests_as"|--> ALS["Amyotrophic<br/>Lateral Sclerosis"]
    Neurodegeneration --|"manifests_as"|--> Parkinsons["Parkinson's<br/>Disease"]
    Neurodegeneration --|"manifests_as"|--> Huntingtons["Huntington's<br/>Disease"]
    Neurodegeneration --|"manifests_as"|--> Ataxia["Ataxia"]
    
    %% Cellular dysfunction pathways
    Protein_Degradation --|"failure_leads_to"|--> Neurodegeneration
    RNA_Processing --|"impairment_causes"|--> Neurodegeneration
    Mitochondrial_Function --|"dysfunction_promotes"|--> Neurodegeneration
    Calcium_Signaling --|"dysregulation_contributes"|--> Neurodegeneration
    
    %% Styling
    style GLA fill:#006494
    style Autophagy fill:#1b5e20
    style Protein_Folding fill:#1b5e20
    style ATG12 fill:#4a1a6b
    style BECN1 fill:#4a1a6b
    style STUB1 fill:#4a1a6b
    style HSPB8 fill:#4a1a6b
    style PPARGC1A fill:#4a1a6b
    style CALCINEURIN fill:#4a1a6b
    style TARDBP fill:#ef5350
    style RNA_Processing fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style ALS fill:#5d4400
    style Parkinsons fill:#5d4400
    style Huntingtons fill:#5d4400
    style Ataxia fill:#5d4400