gene 2,642 words KG: LARS2 2026-03-25
kind:genesection:genesstate:published
Contents

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

🧬 Gene Info
Gene SymbolLARS2
Full NameLeucyl-tRNA Synthetase 2, Mitochondrial
Chromosome3p21.31
Protein TypeSynthetase
Functionencodes a mitochondrial aminoacyl-tRNA synthetase that catalyzes the attachment of leucine to mitochondrial tRNA molecules.
PathwaysDifferentiation, Mitochondrial Function
UniProt IDQ9H3K1
NCBI Gene ID57505
Ensembl IDENSG00000090339
OMIM615912
GeneCardsLARS2
Human Protein AtlasLARS2
Protein ClassAminoacyl-tRNA synthetase
Variant TypeMissense, nonsense, splice site
Associated DiseasesAtaxia, Cognitive Impairment, Ms
InteractionsMFN2, PIEZO1, DRP1, MFN1, RUNX2, ATP
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (29)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (14)

STUB1 — CHIP
gene · KG edge: associated_with
SIL1 Gene
gene · KG edge: associated_with
SETX Gene
gene · KG edge: associated_with
POLG — DNA Polymerase Subunit Gamma
gene · KG edge: associated_with
PNPLA6 Gene — Neuropathy Target Esterase (NTE) in Neuro
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LARS2 inhibits MFN2
LARS2 activates PIEZO1
LARS2 associated_with POLG
LARS2 associated_with SIL1
LARS2 associated_with STUB1
LARS2 associated_with FMR1
LARS2 associated_with TWNK
LARS2 associated_with PNPLA6
LARS2 inhibits DRP1
LARS2 inhibits MFN1