gene 2,253 words KG: FMR1 2026-03-27
kind:genesection:genesstate:published
Contents

FMR1 — Fragile X Messenger Ribonucleoprotein 1

🧬 Gene Info
Gene SymbolFMR1
Full NameFragile X Messenger Ribonucleoprotein 1
ChromosomeXq27.3
Primary Expressionbrain tissue, particularly in neurons of the cerebral cortex, hippocampus, cerebellum, and amygdala
Subcellular Localizationdendritic spines and shafts, where it associates with translating ribosomes and neuronal mRNA granules. This localizatio
Molecular Weight71 kDa
Amino Acids632 aa
PathwaysEr Stress
UniProt ID[Q06787](https://www.uniprot.org/uniprot/Q06787)
Ensembl IDENSG00000102081
GeneCardsFMR1
Human Protein AtlasFMR1
Associated DiseasesAD, ALI, ALS, Alzheimer, Ataxia
Known Drugs/Compoundsrapamycin
InteractionsSNCA, FAM134B, LC3, EPAS1, MIRO1, CTSD
KG Connections589 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (4)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

FMR1 interacts_with SNCA
FMR1 interacts_with FAM134B
FMR1 interacts_with LC3
FMR1 interacts_with EPAS1
FMR1 interacts_with MIRO1
FMR1 interacts_with CTSD
FMR1 interacts_with RB1
FMR1 interacts_with EIF2AK3
FMR1 interacts_with PRKN
FMR1 interacts_with BCL2L11