gene 754 words KG: IL7R 2026-03-24
kind:genesection:genesstate:published
Contents

IL7R Gene - Interleukin-7 Receptor Alpha Chain

🧬 Gene Info
Gene SymbolIL7R
Full NameInterleukin-7 Receptor Alpha Chain
AliasesPage for IL7R Gene
Chromosome5p13.2
FunctionThe IL-7 receptor plays critical roles in immune system development and function
Primary ExpressionT cells, B cells, brain (neurons, microglia)
Amino Acids439 aa
Exons8
UniProt IDP16871
NCBI Gene ID3575
Ensembl IDENSG00000168685
OMIM146661
GeneCardsIL7R
Human Protein AtlasIL7R
Associated DiseasesFibrosis, Inflammation, Ms
InteractionsTXNIP, HSPA1A, CXCR4, CSF1R, ETV6, ZFP36
KG Connections119 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
DOCK2 Gene
gene · KG edge: therapeutic_target
CXCR4 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

IL7R contributes_to JAK2
IL7R contributes_to PDGFRB
IL7R contributes_to NTRK3
IL7R contributes_to CSF1R
IL7R associated_with CCL5
IL7R associated_with AKT
IL7R associated_with CXCL10
IL7R inhibits TXNIP
IL7R inhibits HSPA1A
IL7R inhibits CXCR4