gene 1,902 words KG: CXCR4 2026-03-27
kind:genesection:genesstate:published
Contents

CXCR4 Gene

🧬 Gene Info
Gene SymbolCXCR4
Full NameC-X-C Motif Chemokine Receptor 4
AliasesCD184, fusin, NPYR3, WHIM1
Chromosome2q22.1
Protein FamilyChemokine receptors (GPCR family)
Protein TypeReceptor
FunctionCXCR4 has diverse physiological roles
Molecular Weight39.8 kDa
Amino Acids352 aa
Gene TypeProtein coding
PathwaysNF-κB, PI3K, MAPK pathway, MAPK
UniProt IDP61073
NCBI Gene ID7852
Ensembl IDENSG00000121966
OMIM162643
GeneCardsCXCR4
Human Protein AtlasCXCR4
Associated DiseasesAls, Alzheimer, Autoimmune, Breast Cancer, Cancer, Inflammation
InteractionsSIRT1, CXCL12, HSPA1A, PSD95, MTOR, SYNAPTOPHYSIN
KG Connections316 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: inhibits
BCL2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CXCR4 activates SIRT1
CXCR4 regulates STING
CXCR4 expressed_in ALDH1A3
CXCR4 treats MTOR
CXCR4 treats CCR5
CXCR4 associated_with NAMPT
CXCR4 interacts_with CXCL12
CXCR4 associated_with LAMP1
CXCR4 associated_with VEGFA
CXCR4 inhibits HSPA1A