gene 1,540 words KG: JNK1 2026-03-24
kind:genesection:genesstate:published
Contents

JNK1 (MAPK8)

🧬 Gene Info
Gene SymbolJNK1
AliasesMAPK8
Protein TypeKinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight46 kDa
Amino Acids464 aa
Exons12
Pathwayscascade: **Upstream Activation:**, MAPK, Mapk
Ensembl IDENSG00000107643
GeneCardsJNK1
Human Protein AtlasJNK1
JNK1βLess characterized isoform
Associated DiseasesALS
Known Drugs/Compoundsrapamycin
InteractionsJNK2, BIP, JUN, P38, UBIQUITIN, NLRP3
KG Connections165 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41

Related Analyses (3)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

JNK1 activates JNK2
JNK1 activates BIP
JNK1 activates JUN
JNK1 activates P38
JNK1 therapeutic_target TAK1
JNK1 therapeutic_target P38
JNK1 activates UBIQUITIN
JNK1 therapeutic_target DLK1
JNK1 regulates P38
JNK1 regulates JUN