gene 699 words KG: JUNB 2026-03-24
kind:genesection:genesstate:published
Contents

JUNB Gene

🧬 Gene Info
Gene SymbolJUNB
Chromosome19p13.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight35 kDa
Exons3
PathwaysMAPK, Wnt
Ensembl IDENSG00000171223
GeneCardsJUNB
Human Protein AtlasJUNB
Transactivation domain (N-terminus)Transcriptional activation
DNA-binding domain (basic region)Binds TRE elements
Dimerization domain (leucine zipper)Jun/Fos heterodimerization
Associated DiseasesAtherosclerosis, Diabetes, Ms
Known Drugs/Compoundspokeweed mitogen
InteractionsTGFB1, JUN, PTGS2, C-FOS, C-JUN, FOS
KG Connections94 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: regulates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
FOS Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

JUNB activates M1_MACROPHAGE
JUNB regulates CLOCK
JUNB regulates ARNT
JUNB regulates AKT
JUNB activates TGFB1
JUNB biomarker_for NFKBIA
JUNB biomarker_for TNF
JUNB biomarker_for STXBP2
JUNB biomarker_for TRAF6
JUNB biomarker_for EGR2