gene

FOSB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOSB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

Summary

FOSB Gene

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🧬 Gene Info

Gene Symbol	FOSB
Full Name	FBJ Murine Osteosarcoma Viral Oncogene Homolog B
Chromosome	19q13.32
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	Epigenetic, Immune Response, Nf-Κb, Pi3K/Akt, Toll-Like Receptor
UniProt ID	P53539
NCBI Gene ID	2354
Ensembl ID	ENSG00000125740
OMIM	164772
GeneCards	FOSB
Human Protein Atlas	FOSB
Associated Diseases	neurodegeneration
Interactions	CX3CR1, APP, BDNF, EGR4, SOCS1, EGR1
KG Connections	104 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOSB — AlphaFold P53539 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOSB["<b>FOSB</b>"]
    Als{"Als"}
    FOSB -->|"activates"| Als
    Ms{"Ms"}
    FOSB -->|"activates"| Ms
    CX3CR1["CX3CR1"]
    FOSB -->|"activates"| CX3CR1
    Toll_Like_Receptor(["Toll-Like Receptor"])
    FOSB -->|"activates"| Toll_Like_Receptor
    neurodegeneration["neurodegeneration"]
    FOSB -->|"implicated in"| neurodegeneration
    FOS["FOS"]
    FOS -->|"activates"| FOSB
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| FOSB
    TLR4["TLR4"]
    TLR4 -->|"activates"| FOSB
    C_FOS["C-FOS"]
    C_FOS -->|"activates"| FOSB
    style FOSB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (71)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ms	activates	disease	0.65
Ms	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Fibrosis	activates	disease	0.65
CX3CR1	activates	gene	0.60
APP	inhibits	gene	0.60
BDNF	activates	gene	0.60
EGR4	activates	gene	0.60
SOCS1	inhibits	gene	0.60
EGR1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
CAMK2G	expressed_in	gene	0.60
EGR1	associated_with	gene	0.60
CEBPA	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
CFOS	activates	gene	0.60
RELA	regulates	gene	0.60
TYK2	regulates	gene	0.60
Jnk	regulates	protein	0.60
Mek	regulates	protein	0.60
JUN	inhibits	gene	0.60
JUNB	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
Toll-Like Receptor	activates	pathway	0.60
APP/PS1	inhibits	gene	0.60
Wnt	inhibits	pathway	0.60
Jak-Stat	inhibits	pathway	0.60
MICROGLIA	activates	gene	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Bdnf	activates	protein	0.60
Raf	activates	protein	0.60
C-FOS	activates	gene	0.60
Interneuron	activates	cell_type	0.60
MAPK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
Ubiquitin	activates	protein	0.60
Akt	activates	protein	0.60
Pi3K	activates	protein	0.60
EXERCISE	inhibits	gene	0.60

Incoming (33)

Source	Relation	Type	Str
FOS	activates	gene	0.60
TLR4	activates	gene	0.60
EGR1	inhibits	gene	0.60
SOCS1	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
EGR4	activates	gene	0.60
BDNF	activates	gene	0.60
PKC	activates	gene	0.60
DNMT1	activates	gene	0.60
FOS	expressed_in	gene	0.60
MYC	associated_with	gene	0.60
ERBB4	expressed_in	gene	0.60
RELB	regulates	gene	0.60
STAT1	regulates	gene	0.60
CD40	activates	gene	0.60
FOS	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
C-FOS	activates	gene	0.60
JAK	inhibits	gene	0.60
ANXIETY	inhibits	gene	0.60
WNT	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
RNA	activates	gene	0.60
DNA	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
WT1	expressed_in	gene	0.60
ERBB2	expressed_in	gene	0.60
C-JUN	regulates	gene	0.60
AMPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FOSB

Understanding Entity Pages

Summary

Wiki Pages (14)

FOSB Gene

Transcription Regulation Pathway

fosb-protein

JUND Gene - JunD Transcription Factor

CFOS Gene

Parafascicular Thalamic Nucleus

Orbitofrontal Cortex Pyramidal Neurons

Posterior Parietal Cortex Neurons

JUN Protein

FOS Protein

JUN Gene

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma