gene 1,286 words KG: KIF5A
Contents

KIF5A Gene

🧬 Gene Info
Gene SymbolKIF5A
Chromosome12q13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionNeurons (CNS and PNS), particularly in axons
Molecular Weight103 kDa
Amino Acids350 aa
PathwaysCargo Transport, Intracellular Transport, autophagic flux, lysosomal axonal transport, ubiquitin-proteasome
UniProt IDP33175
NCBI Gene ID3790
Ensembl IDENSG00000130224
OMIM176602
GeneCardsKIF5A
Human Protein AtlasKIF5A
Associated DiseasesAls, Alzheimer's disease, Amyotrophic Lateral Sclerosis, disease, epilepsy, Ms
Known Drugs/CompoundsTMT
InteractionsALS, AUTOPHAGY, C21ORF2, HNRNPA2B1, KIF5B, KIF5C
SciDEX HypothesesCytoskeletal Transport Selectivity Enhancement
KG Connections74 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Axonal RNA Transport Reconstitution
Score: 0.70
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

NeuRon Therapeutics
company · KG edge: contributes_to
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Mitochondria
entity · KG edge: contributes_to
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
KIF5C Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

KIF5C interacts_with KIF5A
KIF5A interacts_with KIF5C
TMT inhibits KIF5A
KIF5A regulates lysosomal axonal transport
KIF5A regulates autophagic flux
P62 associated_with KIF5A
SQSTM1 associated_with KIF5A
TRAK1 associated_with KIF5A
KIF5A interacts_with PRV
KIF5A interacts_with Kinesin

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