gene 1,286 words KG: KIF5A 2026-03-22
kind:genesection:genesstate:published
Contents

KIF5A Gene

🧬 Gene Info
Gene SymbolKIF5A
Chromosome12q13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionNeurons (CNS and PNS), particularly in axons
Molecular Weight103 kDa
Amino Acids350 aa
PathwaysCargo Transport, Intracellular Transport, autophagic flux, lysosomal axonal transport, ubiquitin-proteasome
UniProt IDP33175
NCBI Gene ID3790
Ensembl IDENSG00000130224
OMIM176602
GeneCardsKIF5A
Human Protein AtlasKIF5A
Symbol [@jnk2005] KIF5A [@kifa2019] [@kifa2003] [@kifa2011] Full Name [@mitochondrial2012] Kinesin Family Member 5A [@axonal2011] Chromosome12q13.3
Associated DiseasesAls, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ms, Spastic Paraplegia Type 10, disease
Known Drugs/CompoundsTMT
InteractionsKIF5C, Kinesin, KIF5B, NEK1, TBK1, NEUROTOXICITY
KG Connections79 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Axonal RNA Transport Reconstitution
Score: 0.45
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
KIF5C Gene
gene · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Mitochondria
entity · KG edge: contributes_to
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

KIF5A interacts_with KIF5C
KIF5A regulates lysosomal axonal transport
KIF5A regulates autophagic flux
KIF5A interacts_with PRV
KIF5A interacts_with Kinesin
KIF5A associated_with Kinesin
KIF5A interacts_with epilepsy
KIF5A associated_with epilepsy
KIF5A involved_in Intracellular Transport
KIF5A interacts_with TRAK2