gene

C21ORF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C21ORF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

1Analyses

24Outgoing

17Incoming

Summary

C21ORF2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	C21ORF2
Full Name	C21orf2 — Chromosome 21 Open Reading Frame 2
Aliases	Chromosome 21 Open Reading Frame 2
Chromosome	21
Protein Type	Gene
Function	C21orf2 participates in centrosome and basal-body biology, helping coordinate ciliary assembly and organization.[@wheway2015][@reiter2017] In neuronal systems, cilia regulate signaling pathways releva
Subcellular Localization	ciliary/centrosomal compartments and variants in both genes appear in ALS cohorts.[@van2016][@kenna2016]
NCBI Gene ID	Search NCBI
GeneCards	C21ORF2
Human Protein Atlas	C21ORF2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis
Interactions	KIF5A, NEK1, TBK1, ALS
KG Connections	41 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    C21ORF2["<b>C21ORF2</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    C21ORF2 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    C21ORF2 -->|"therapeutic target"| Ms
    Als{"Als"}
    C21ORF2 -->|"associated with"| Als
    NEK1["NEK1"]
    C21ORF2 -->|"associated with"| NEK1
    SOD1["SOD1"]
    C21ORF2 -->|"therapeutic target"| SOD1
    TBK1["TBK1"]
    C21ORF2 -->|"associated with"| TBK1
    GENES["GENES"]
    C21ORF2 -->|"associated with"| GENES
    DNA["DNA"]
    C21ORF2 -->|"therapeutic target"| DNA
    CHCHD10["CHCHD10"]
    C21ORF2 -->|"associated with"| CHCHD10
    neurodegeneration["neurodegeneration"]
    C21ORF2 -->|"implicated in"| neurodegeneration
    CHCHD10 -->|"associated with"| C21ORF2
    style C21ORF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.65
NEK1	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
TBK1	associated_with	gene	0.60
CHCHD10	associated_with	gene	0.60
VCP	associated_with	gene	0.60
KIF5A	interacts_with	gene	0.60
NEK1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
NEK1	activates	gene	0.60
NEK1	regulates	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Dna Repair	therapeutic_target	pathway	0.60
neurons	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
DNA	regulates	gene	0.60

Incoming (17)

Source	Relation	Type	Str
CHCHD10	associated_with	gene	0.60
NEK1	contributes_to	gene	0.60
VCP	contributes_to	gene	0.60
TBK1	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
ALS	contributes_to	gene	0.60
MOTOR NEURONS	implicated_in	gene	0.60
MATR3	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
ALS	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	interacts_with	gene	0.60
ALS	expressed_in	gene	0.60
ALS	regulates	gene	0.60
ALS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found