gene 648 words KG: L1CAM 2026-03-30
kind:genesection:genesstate:published
Contents

L1CAM (L1 Cell Adhesion Molecule)

🧬 Gene Info
Gene SymbolL1CAM
ChromosomeXq28
Protein TypeImmunoglobulin superfamily CAM
Functionis a neural cell adhesion molecule that plays critical roles in neuronal development, axonal guidance, myelination, and synaptic plasticity.
Primary ExpressionCNS (neurons, glia), PNS, developing brain
Amino Acids1400 aa
PathwaysMAPK, PI3K
UniProt IDP32004
NCBI Gene ID3909
GeneCardsL1CAM
Human Protein AtlasL1CAM
Protein ClassImmunoglobulin superfamily CAM
Ankyrin-GCytoplasmic tail binding
Integrins (α5β1, αvβ3)Heterophilic
TAG-1/Axonin-1Heterophilic
Associated Diseasesneurodegeneration
InteractionsDEMENTIA, AGING, LC3, ATG12, AUTOPHAGY, ALZHEIMER
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (14)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: interacts_with
MTOR Gene
gene · KG edge: expressed_in
MAP1LC3A Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

L1CAM expressed_in AKT
L1CAM expressed_in MTOR
L1CAM associated_with LC3
L1CAM interacts_with LC3
L1CAM interacts_with ATG12
L1CAM binds
L1CAM mediates Aβ Elimination
L1CAM transports Autophagosome
L1CAM biomarker_for MOG
L1CAM expressed_in Tumor