gene 1,271 words KG: MST1 2026-03-22
kind:genesection:genesstate:published
Contents

MST1 Gene

🧬 Gene Info
Gene SymbolMST1
Chromosome19p13.3
Protein TypeSerine/Threonine Kinase
Functionencodes a serine/threonine kinase that belongs to the Hippo signaling pathway.
Primary Expressionvarious tissues:
Molecular Weight~56 kDa
Amino Acids487 aa
PathwaysPI3K, MAPK pathway
UniProt IDQ13043
NCBI Gene ID6789
Ensembl IDENSG00000101189
OMIM604995
GeneCardsMST1
Human Protein AtlasMST1
Alternative NamesSTK4, KRS2, MACROPHAGE STIMULATING 1
Associated DiseasesAlzheimer's disease, Ms
InteractionsLATS1, CGAS, GATA3, GATA2, NFATC1, HDAC6
KG Connections152 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

See Also (11)

huntington-disease-treatment
therapeutic · KG edge: activates
Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates

Knowledge Graph (12 edges)

MST1 activates LATS1
MST1 interacts_with PGC1α
MST1 regulates mitochondrial homeostasis
MST1 activates neuronal apoptosis
MST1 activates cognitive decline
MST1 activates cognitive impairment
MST1 activates CGAS
MST1 regulates QKI
MST1 regulates NCL
MST1 regulates PI3K