protein

CCNF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections
0Hypotheses
1Analyses
50Outgoing
25Incoming

Summary

Page for CCNF Protein (Cyclin F)

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🔬 Protein Info
Gene SymbolCCNF
AliasesCyclin F
FunctionCcnf Protein (Cyclin F) plays an important role in the study of neurodegenerative diseases
Primary Expressionmost tissues, with highest expression in:
Subcellular Localization</th><td>Nucleus, Cytoplasm</td></tr>
Molecular Weight89.5 kDa
Amino Acids786 aa
PathwaysApoptosis, Cell Cycle, apoptosis
GeneCardsCCNF
Human Protein AtlasCCNF
Associated Diseasesfrontotemporal dementia
InteractionsCDKN1A, TIA1, CHCHD10, NEK1, TBK1, SFPQ
KG Connections113 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

CCNF Protein (Cyclin F)

protein · 1530 words

Proteasomal Pathway in Neurodegeneration

mechanism · 1803 words

CCNF Protein

protein · 1360 words

MFSD8 — Major Facilitator Superfamily Domain Containing 8

gene · 857 words

Cyclin F Protein

protein · 572 words

GLT8D1 — Glycosyltransferase 8 Domain Containing 1

gene · 562 words

Pathway Diagram

graph TD
    CCNF["<b>CCNF</b>"]
    Dementia["Dementia"]
    CCNF -->|"expressed in"| Dementia
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CCNF -->|"expressed in"| Amyotrophic_Lateral_Sclerosis
    ALS["ALS"]
    CCNF -->|"expressed in"| ALS
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    CCNF -->|"expressed in"| Frontotemporal_Dementia
    DEMENTIA["DEMENTIA"]
    CCNF -->|"expressed in"| DEMENTIA
    TDP_43["TDP-43"]
    CCNF -->|"expressed in"| TDP_43
    TPRKB["TPRKB"]
    CCNF -->|"activates"| TPRKB
    MAPT["MAPT"]
    CCNF -->|"expressed in"| MAPT
    CDKN1A["CDKN1A"]
    CCNF -->|"activates"| CDKN1A
    AND["AND"]
    CCNF -->|"activates"| AND
    APOPTOSIS["APOPTOSIS"]
    CCNF -->|"activates"| APOPTOSIS
    SMN["SMN"]
    CCNF -->|"expressed in"| SMN
    GENES["GENES"]
    CCNF -->|"expressed in"| GENES
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    CCNF -->|"expressed in"| AMYOTROPHIC_LATERAL_SCLEROSIS
    TIA1["TIA1"]
    CCNF -->|"activates"| TIA1
    CNTN4["CNTN4"]
    CCNF -->|"expressed in"| CNTN4
    Tdp_43["Tdp-43"]
    CCNF -->|"expressed in"| Tdp_43
    Apoptosis["Apoptosis"]
    CCNF -->|"activates"| Apoptosis
    Er_Stress["Er Stress"]
    CCNF -->|"expressed in"| Er_Stress
    Cell_Cycle["Cell Cycle"]
    CCNF -->|"activates"| Cell_Cycle
    TBC1D24["TBC1D24"]
    TBC1D24 -->|"expressed in"| CCNF
    PLIN4["PLIN4"]
    PLIN4 -->|"expressed in"| CCNF
    FUS["FUS"]
    FUS -->|"expressed in"| CCNF
    ATXN2["ATXN2"]
    ATXN2 -->|"expressed in"| CCNF
    HNRNPA2B1["HNRNPA2B1"]
    HNRNPA2B1 -->|"expressed in"| CCNF
    BID["BID"]
    BID -->|"expressed in"| CCNF
    NEURON["NEURON"]
    NEURON -->|"expressed in"| CCNF
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"expressed in"| CCNF
    ALS["ALS"]
    ALS -->|"expressed in"| CCNF
    Ca1["Ca1"]
    CCNF -->|"expressed in"| Ca1

Outgoing (88)

TargetRelationTypeStr
Spinal Muscular Atrophyexpressed_indisease0.65
Dementiaexpressed_indisease0.65
Amyotrophic Lateral Sclerosisexpressed_indisease0.65
ALSexpressed_indisease0.65
Frontotemporal Dementiaexpressed_indisease0.65

Incoming (25)

SourceRelationTypeStr
TBC1D24expressed_ingene0.60
PLIN4expressed_ingene0.60
FUSexpressed_ingene0.60
ATXN2expressed_ingene0.60
HNRNPA2B1expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found