Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CCNF |
| Aliases | Cyclin F |
| Function | Ccnf Protein (Cyclin F) plays an important role in the study of neurodegenerative diseases |
| Primary Expression | most tissues, with highest expression in: |
| Subcellular Localization | </th><td>Nucleus, Cytoplasm</td></tr> |
| Molecular Weight | 89.5 kDa |
| Amino Acids | 786 aa |
| Pathways | Apoptosis, Cell Cycle, apoptosis |
| GeneCards | CCNF |
| Human Protein Atlas | CCNF |
| Associated Diseases | frontotemporal dementia |
| Interactions | CDKN1A, TIA1, CHCHD10, NEK1, TBK1, SFPQ |
| KG Connections | 113 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CCNF["<b>CCNF</b>"]
Dementia["Dementia"]
CCNF -->|"expressed in"| Dementia
Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
CCNF -->|"expressed in"| Amyotrophic_Lateral_Sclerosis
ALS["ALS"]
CCNF -->|"expressed in"| ALS
Frontotemporal_Dementia["Frontotemporal Dementia"]
CCNF -->|"expressed in"| Frontotemporal_Dementia
DEMENTIA["DEMENTIA"]
CCNF -->|"expressed in"| DEMENTIA
TDP_43["TDP-43"]
CCNF -->|"expressed in"| TDP_43
TPRKB["TPRKB"]
CCNF -->|"activates"| TPRKB
MAPT["MAPT"]
CCNF -->|"expressed in"| MAPT
CDKN1A["CDKN1A"]
CCNF -->|"activates"| CDKN1A
AND["AND"]
CCNF -->|"activates"| AND
APOPTOSIS["APOPTOSIS"]
CCNF -->|"activates"| APOPTOSIS
SMN["SMN"]
CCNF -->|"expressed in"| SMN
GENES["GENES"]
CCNF -->|"expressed in"| GENES
AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
CCNF -->|"expressed in"| AMYOTROPHIC_LATERAL_SCLEROSIS
TIA1["TIA1"]
CCNF -->|"activates"| TIA1
CNTN4["CNTN4"]
CCNF -->|"expressed in"| CNTN4
Tdp_43["Tdp-43"]
CCNF -->|"expressed in"| Tdp_43
Apoptosis["Apoptosis"]
CCNF -->|"activates"| Apoptosis
Er_Stress["Er Stress"]
CCNF -->|"expressed in"| Er_Stress
Cell_Cycle["Cell Cycle"]
CCNF -->|"activates"| Cell_Cycle
TBC1D24["TBC1D24"]
TBC1D24 -->|"expressed in"| CCNF
PLIN4["PLIN4"]
PLIN4 -->|"expressed in"| CCNF
FUS["FUS"]
FUS -->|"expressed in"| CCNF
ATXN2["ATXN2"]
ATXN2 -->|"expressed in"| CCNF
HNRNPA2B1["HNRNPA2B1"]
HNRNPA2B1 -->|"expressed in"| CCNF
BID["BID"]
BID -->|"expressed in"| CCNF
NEURON["NEURON"]
NEURON -->|"expressed in"| CCNF
HNRNPA1["HNRNPA1"]
HNRNPA1 -->|"expressed in"| CCNF
ALS["ALS"]
ALS -->|"expressed in"| CCNF
Ca1["Ca1"]
CCNF -->|"expressed in"| Ca1| Target | Relation | Type | Str |
|---|---|---|---|
| Spinal Muscular Atrophy | expressed_in | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Frontotemporal Dementia | expressed_in | disease | 0.65 |
| Frontotemporal Dementia | encodes | disease | 0.65 |
| Dementia | encodes | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | encodes | disease | 0.65 |
| Als | encodes | disease | 0.65 |
| TDP-43 | expressed_in | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| CDKN1A | activates | gene | 0.60 |
| SMN | expressed_in | gene | 0.60 |
| TIA1 | activates | gene | 0.60 |
| CNTN4 | expressed_in | gene | 0.60 |
| TBC1D24 | encodes | gene | 0.60 |
| BID | encodes | gene | 0.60 |
| HNRNPA2B1 | expressed_in | gene | 0.60 |
| PLIN4 | expressed_in | gene | 0.60 |
| HNRNPA1 | expressed_in | gene | 0.60 |
| ATXN2 | expressed_in | gene | 0.60 |
| FUS | expressed_in | gene | 0.60 |
| CTSF | implicated_in | gene | 0.60 |
| DNAJC7 | implicated_in | gene | 0.60 |
| GLT8D1 | implicated_in | gene | 0.60 |
| KIF5A | implicated_in | gene | 0.60 |
| MFSD8 | implicated_in | gene | 0.60 |
| NEK1 | implicated_in | gene | 0.60 |
| TBK1 | implicated_in | gene | 0.60 |
| TBP | implicated_in | gene | 0.60 |
| CHCHD10 | interacts_with | gene | 0.60 |
| NEK1 | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| SFPQ | interacts_with | gene | 0.60 |
| CHCHD10 | causes | gene | 0.60 |
| CHCHD2 | causes | gene | 0.60 |
| CHMP2B | causes | gene | 0.60 |
| CYLD | causes | gene | 0.60 |
| FUS | causes | gene | 0.60 |
| GRN | causes | gene | 0.60 |
| MAPT | causes | gene | 0.60 |
| OPTN | causes | gene | 0.60 |
| PRNP | causes | gene | 0.60 |
| SIGMAR1 | causes | gene | 0.60 |
| SQSTM1 | causes | gene | 0.60 |
| TARDBP | causes | gene | 0.60 |
| TBK1 | causes | gene | 0.60 |
| TMEM106B | causes | gene | 0.60 |
| UBQLN2 | causes | gene | 0.60 |
| VCP | causes | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TBC1D24 | expressed_in | gene | 0.60 |
| PLIN4 | expressed_in | gene | 0.60 |
| FUS | expressed_in | gene | 0.60 |
| ATXN2 | expressed_in | gene | 0.60 |
| HNRNPA2B1 | expressed_in | gene | 0.60 |
| BID | expressed_in | gene | 0.60 |
| HNRNPA1 | expressed_in | gene | 0.60 |
| FUS | encodes | gene | 0.60 |
| PLIN4 | encodes | gene | 0.60 |
| HNRNPA2B1 | encodes | gene | 0.60 |
| ATXN2 | encodes | gene | 0.60 |
| HNRNPA1 | encodes | gene | 0.60 |
| CNTN4 | encodes | gene | 0.60 |
| SMN | encodes | gene | 0.60 |
| ANXA11 | causes | gene | 0.60 |
| ANXA11 | associated_with | gene | 0.60 |
| NEURON | expressed_in | gene | 0.60 |
| ALS | expressed_in | gene | 0.60 |
| NEURON | encodes | gene | 0.60 |
| ALS | encodes | gene | 0.60 |
| DEMENTIA | encodes | gene | 0.60 |
| ALS | interacts_with | gene | 0.60 |
| ALS | implicated_in | gene | 0.60 |
| ALS | regulates | gene | 0.60 |
| CDKN1A | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||