gene 509 words KG: NPTXR 2026-03-21
kind:genesection:genesstate:published
Contents

NPTXR — Neuronal Pentraxin Receptor

🧬 Gene Info
Gene SymbolNPTXR
Full NameNeuronal Pentraxin Receptor
Protein TypeReceptor
FunctionNeuronal Pentraxin Receptor (NPTXR) is a membrane protein that serves as the primary receptor for the neuronal pentraxin family, including NPTX1 and NPTX2.
Subcellular Localizationboth pre- and postsynaptic membranes at excitatory synapses
Molecular Weight50 kDa
Ensembl IDENSG00000162591
GeneCardsNPTXR
Human Protein AtlasNPTXR
Associated DiseasesAls, Alzheimer, Dementia, Diabetes, Ms
InteractionsBDNF, TRKB, DEMENTIA, ROS
KG Connections20 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Dementia Australia
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
TRKB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NPTXR activates BDNF
NPTXR activates TRKB
NPTXR associated_with STAT3
NPTXR activates DEMENTIA
NPTXR activates Aging
NPTXR activates Dementia
NPTXR associated_with DEMENTIA
NPTXR associated_with ALZHEIMER
NPTXR associated_with AND
NPTXR associated_with ALZHEIMER'S DISEASE