gene

JAM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
32Outgoing
12Incoming

Summary

JAM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, implicated in. Associated with ALS, Aging, Als. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolJAM2
Full NameJunctional Adhesion Molecule 2
AliasesPage for JAM2
FunctionJAM2 mediates homophilic (JAM2-JAM2) and heterophilic (JAM2-JAM3) interactions at cell junctions
Primary Expressionbrain endothelial cells forming the blood-brain barrier, with lower expression in neurons (particularly in the [hippocampus](/bra
Ensembl IDENSG00000176182
GeneCardsJAM2
Human Protein AtlasJAM2
Associated DiseasesALS, Aging, Ataxia, Ms, Parkinson
InteractionsPDGFB, PDGFRB, MYORG, SLC20A2, XPR1, CMPK2
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

JAM2 - Junctional Adhesion Molecule 2

gene · 509 words

Primary Familial Brain Calcification (Fahr's Disease)

disease · 1791 words

Fahr's Disease

disease · 737 words

Genes

index · 271 words

Pathway Diagram

graph TD
    JAM2["<b>JAM2</b>"]
    Primary_Familial_Brain_Calcification{"Primary Familial Brain Calcification"}
    JAM2 -->|"associated with"| Primary_Familial_Brain_Calcification
    Aging{"Aging"}
    JAM2 -->|"associated with"| Aging
    Ms{"Ms"}
    JAM2 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    JAM2 -->|"associated with"| Parkinson
    Als{"Als"}
    JAM2 -->|"associated with"| Als
    Ataxia{"Ataxia"}
    JAM2 -->|"associated with"| Ataxia
    ALS{"ALS"}
    JAM2 -->|"associated with"| ALS
    PDGFRB["PDGFRB"]
    JAM2 -->|"associated with"| PDGFRB
    PDGFB["PDGFB"]
    JAM2 -->|"associated with"| PDGFB
    GENES["GENES"]
    JAM2 -->|"associated with"| GENES
    XPR1["XPR1"]
    JAM2 -->|"associated with"| XPR1
    SLC20A2["SLC20A2"]
    JAM2 -->|"associated with"| SLC20A2
    JUN["JUN"]
    JUN -->|"associated with"| JAM2
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| JAM2
    PDGFB -->|"associated with"| JAM2
    SLC20A2 -->|"associated with"| JAM2
    AND["AND"]
    AND -->|"associated with"| JAM2
    GENES -->|"associated with"| JAM2
    style JAM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Primary Familial Brain Calcificationassociated_withdisease0.95
Primary Familial Brain Calcificationcausesdisease0.95
Agingassociated_withdisease0.65
Msassociated_withdisease0.65
Parkinsonassociated_withdisease0.65

Incoming (12)

SourceRelationTypeStr
JUNassociated_withgene0.60
PDGFBassociated_withgene0.60
PDGFRBassociated_withgene0.60
MITOCHONDRIAL DYSFUNCTIONassociated_withgene0.60
SLC20A2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found