Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JAM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
JAM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, implicated in. Associated with ALS, Aging, Als. Connected to 25 entities in the SciDEX knowledge graph.
| Gene Symbol | JAM2 |
| Full Name | Junctional Adhesion Molecule 2 |
| Aliases | Page for JAM2 |
| Function | JAM2 mediates homophilic (JAM2-JAM2) and heterophilic (JAM2-JAM3) interactions at cell junctions |
| Primary Expression | brain endothelial cells forming the blood-brain barrier, with lower expression in neurons (particularly in the [hippocampus](/bra |
| Ensembl ID | ENSG00000176182 |
| GeneCards | JAM2 |
| Human Protein Atlas | JAM2 |
| Associated Diseases | ALS, Aging, Ataxia, Ms, Parkinson |
| Interactions | PDGFB, PDGFRB, MYORG, SLC20A2, XPR1, CMPK2 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
JAM2["<b>JAM2</b>"]
Primary_Familial_Brain_Calcification{"Primary Familial Brain Calcification"}
JAM2 -->|"associated with"| Primary_Familial_Brain_Calcification
Aging{"Aging"}
JAM2 -->|"associated with"| Aging
Ms{"Ms"}
JAM2 -->|"associated with"| Ms
Parkinson{"Parkinson"}
JAM2 -->|"associated with"| Parkinson
Als{"Als"}
JAM2 -->|"associated with"| Als
Ataxia{"Ataxia"}
JAM2 -->|"associated with"| Ataxia
ALS{"ALS"}
JAM2 -->|"associated with"| ALS
PDGFRB["PDGFRB"]
JAM2 -->|"associated with"| PDGFRB
PDGFB["PDGFB"]
JAM2 -->|"associated with"| PDGFB
GENES["GENES"]
JAM2 -->|"associated with"| GENES
XPR1["XPR1"]
JAM2 -->|"associated with"| XPR1
SLC20A2["SLC20A2"]
JAM2 -->|"associated with"| SLC20A2
JUN["JUN"]
JUN -->|"associated with"| JAM2
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| JAM2
PDGFB -->|"associated with"| JAM2
SLC20A2 -->|"associated with"| JAM2
AND["AND"]
AND -->|"associated with"| JAM2
GENES -->|"associated with"| JAM2
style JAM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Primary Familial Brain Calcification | associated_with | disease | 0.95 |
| Primary Familial Brain Calcification | causes | disease | 0.95 |
| Aging | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| PDGFRB | associated_with | gene | 0.60 |
| PDGFB | associated_with | gene | 0.60 |
| OCLN | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| PDGFRB | interacts_with | gene | 0.60 |
| PDGFRB | binds_to | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| XPR1 | associated_with | gene | 0.60 |
| SLC20A2 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MYORG | associated_with | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 0.60 |
| CMPK2 | associated_with | gene | 0.60 |
| Pdgf | associated_with | protein | 0.60 |
| MYORG | interacts_with | gene | 0.60 |
| SLC20A2 | interacts_with | gene | 0.60 |
| XPR1 | interacts_with | gene | 0.60 |
| Cerebellum | expressed_in | brain_region | 0.55 |
| White Matter | expressed_in | brain_region | 0.55 |
| Thalamus | expressed_in | brain_region | 0.55 |
| PDGFB | interacts_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| JUN | associated_with | gene | 0.60 |
| PDGFB | associated_with | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 0.60 |
| SLC20A2 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CMPK2 | associated_with | gene | 0.60 |
| MYORG | associated_with | gene | 0.60 |
| XPR1 | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| CMPK2 | interacts_with | gene | 0.60 |
| PDGFRB | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||