| Gene Symbol | PPP2R2B |
| Protein Family | PP2A B subunit family (B55/B/PR55) |
| Function | Regulatory subunit targeting PP2A to specific substrates |
| Primary Expression | Neuronal tissue, particularly cerebellum and cerebral cortex |
| Pathways | Autophagy, Mitophagy |
| GeneCards | PPP2R2B |
| Human Protein Atlas | PPP2R2B |
| PP2A complex | Forms heterotrimeric complex with catalytic (C) and scaffolding (A) subunits |
| Dephosphorylates [tau](/proteins/tau) | Regulates tau phosphorylation at multiple sites |
| Modulates neurotransmission | Targets synaptic proteins |
| Cell cycle regulation | Neuronal cell cycle control |
| Repeat length | Normal < 40, pathogenic > 51 |
| Inheritance | Autosomal dominant |
| Onset | Typically in the 4th-5th decade |
| Associated Diseases | Huntington's disease |
| Interactions | PRKN, PTEN, GAPDH, MAP1LC3B, OPTN, PINK1 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |