Contents

RAMP1

🧬 Gene Info

Gene Symbol	RAMP1
Aliases	Receptor Activity Modifying Protein 1
Chromosome	2q36.1
Protein Type	Chaperone
Function	encodes a single-pass membrane protein that functions as an essential chaperone for G protein-coupled receptors (GPCRs).
Primary Expression	sensory neurons, the brain, cardiovascular system, and immune cells
Amino Acids	175 aa
Exons	6
Ensembl ID	ENSG00000132329
GeneCards	RAMP1
Human Protein Atlas	RAMP1
N-terminal extracellular domain	Large extracellular N-terminus (~130 amino acids) that forms the ligand-binding pocket with the GPCR
Single transmembrane helix	A 22-amino acid hydrophobic transmembrane domain anchoring RAMP1 to the cell membrane
C-terminal intracellular tail	Short cytoplasmic domain (~10 amino acids)
Sensory neurons	Highest expression in trigeminal ganglion and dorsal root ganglia
Associated Diseases	Als, Alzheimer, Atherosclerosis
Interactions	BDNF, CREB1, CRH, CRHR1, FKBP5, IL18BP
KG Connections	58 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph