| Gene Symbol | IL18 |
| Full Name | Interleukin-18 |
| Chromosome | 11q22.2-q22.3 |
| Function | Gene expression: The IL18 gene is induced by NF-κB and AP-1 transcription factors in response to TLR ligands, TNF, and IL-1β |
| Molecular Weight | 24 kDa |
| Amino Acids | 192 aa |
| Pathways | NF-κB |
| UniProt ID | [Q14116](https://www.uniprot.org/uniprot/Q14116) |
| Ensembl ID | ENSG00000150782 |
| GeneCards | IL18 |
| Human Protein Atlas | IL18 |
| Pro-IL-18 (24 kDa) | 192 amino acid precursor |
| N-terminal propeptide | Removed by caspase-1 cleavage |
| Mature IL-18 (18 kDa) | 157 amino acid active cytokine |
| β-trefoil fold | Characteristic of IL-1 cytokine family |
| Associated Diseases | ALS, Alcohol Use Disorder, Alzheimer, Fibrosis, Inflammation, Ms |
| Interactions | FKBP5, CRH, CRHR1, NR3C1, BDNF, TNF |
| KG Connections | 338 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |