gene 2,320 words KG: RORC 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

RORC Gene

🧬 Gene Info
Gene SymbolRORC
Full NameRAR-Related Orphan Receptor C
Chromosome1q21.2
Protein TypeReceptor
FunctionThe circadian transcriptional-translational feedback loop operates as follows
UniProt ID[P51586](https://www.uniprot.org/uniprot/P51586)
Ensembl IDENSG00000143357
GeneCardsRORC
Human Protein AtlasRORC
Metabolic genesGLUT4, PEPCK, fatty acid oxidation enzymes
Immune genesIL-17, IL-22, antimicrobial peptides
Clock genesNR1D1 (Rev-Erbα), NPAS2
Neuronal genesSynaptic plasticity factors, neurotransmitter receptors
Associated DiseasesAlzheimer's disease, Parkinson's disease
Known Drugs/Compoundspaeoniflorin
InteractionsFOXP3, AHR, STAT3, CYTOKINES, Cytokine, IL-22
KG Connections62 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Multi-Modal Stress Response Harmonization
Score: 0.60
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: expressed_in
JUN Gene
gene · KG edge: expressed_in
FOXP3 (Forkhead Box P3)
gene · KG edge: activates
CHI3L1 Gene
gene · KG edge: expressed_in
CD4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RORC therapeutic_target CD4
RORC activates FOXP3
RORC associated_with CD4
RORC associated_with CD14
RORC therapeutic_target CD14
RORC inhibits AHR
RORC expressed_in JUN
RORC interacts_with paeoniflorin
RORC drives Th17 cell differentiation
RORC interacts_with STAT3