gene 2,320 words KG: RORC
Contents

RORC Gene

🧬 Gene Info
Gene SymbolRORC
Full NameRAR-Related Orphan Receptor C
Chromosome1q21.2
Protein TypeReceptor
FunctionThe circadian transcriptional-translational feedback loop operates as follows
UniProt ID[P51586](https://www.uniprot.org/uniprot/P51586)
Ensembl IDENSG00000143357
GeneCardsRORC
Human Protein AtlasRORC
Metabolic genesGLUT4, PEPCK, fatty acid oxidation enzymes
Immune genesIL-17, IL-22, antimicrobial peptides
Clock genesNR1D1 (Rev-Erbα), NPAS2
Neuronal genesSynaptic plasticity factors, neurotransmitter receptors
Associated DiseasesAlzheimer's disease, Parkinson's disease
Known Drugs/Compoundspaeoniflorin
InteractionsAHR, Cytokine, CYTOKINES, FOXP3, IL-22, STAT3
KG Connections62 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: expressed_in
CD14 — CD14 Molecule
gene · KG edge: associated_with
CD4 Gene
gene · KG edge: associated_with
CHI3L1 Gene
gene · KG edge: expressed_in
FOXP3 (Forkhead Box P3)
gene · KG edge: activates

Knowledge Graph (12 edges)

CD14 therapeutic_target RORC
RORC therapeutic_target CD4
RORC activates FOXP3
CD4 therapeutic_target RORC
FOXP3 regulates RORC
FOXP3 activates RORC
RORC associated_with CD4
RORC associated_with CD14
CD14 treats RORC
CD4 treats RORC

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